Research on Water-Soluble Constituents and Anti-Aging Effect of the Leaves of Nelumbo nucifera Gaertn

被引：0

作者：

Cheng, Rong-Qian ^{[1
]}

Zhang, Heyanhao ^{[1
]}

Chang, Jun ^{[1
]}

机构：

[1] Fudan Univ, Human Phenome Inst, Sch Pharm, 825 Zhangheng Rd, Shanghai 201023, Peoples R China

来源：

NATURAL PRODUCT COMMUNICATIONS | 2024年 / 19卷 / 08期

关键词：

Nelumbo nucifera; water-soluble constituents; structure determination; flavonoids; anti-aging activity; ANTIOXIDANT ACTIVITY;

D O I：

10.1177/1934578X241271623

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Objective: This study aimed to isolate and elucidate the structure of water-soluble constituents from Nelumbo nucifera Gaertn. leaves and evaluate their anti-aging effect. Methods: The natural products were isolated from the 60% aqueous acetone extract of the leaves of N. nucifera by column chromatography on MCI gel CHP 20P, YMC-Gel ODS-AQ-HG, and TSK gel Toyopearl HW-40F. Their structures were elucidated using high-resolution-electrospray ionization-mass spectrometry, one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy, and electronic circular dichroism spectroscopy. The anti-aging activity was evaluated in the Caenorhabditis elegans model. Results/Conclusion: One novel flavonoid nuciferanoid (1), together with eleven known compounds, were isolated from the extract of the leaves of N. nucifera. Among them, compound 1 could be a starting point for further development of anti-aging drugs.

引用

页数：5

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