Synthesis and characterization of fullerene-based nanocarrier for targeted delivery of quercetin to the brain

被引：2

作者：

Palai, Amit Kumar ^{[1
]}

Kumar, Amit ^{[1
]}

Mazahir, Farhan ^{[1
]}

Sharma, Ankita ^{[2
]}

Yadav, Awesh K. ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res NIPER Raebareli, Dept Pharmaceut, Lucknow 226002, India

[2] Natl Inst Pharmaceut Educ & Res NIPER Raebareli, Cell Culture facil, Lucknow 226002, India

来源：

THERAPEUTIC DELIVERY | 2024年 / 15卷 / 07期

关键词：

Alzheimer's disease; fullerene; nasal ciliotoxicity; quercetin; reactive oxygen species; OXIDATIVE STRESS; NANOPARTICLES; DISSOLUTION; SOLUBILITY; MODEL;

D O I：

10.1080/20415990.2024.2365620

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim: Preparation of quercetin fullerene conjugate (QFC) for nose-to-brain delivery and their in vitro and ex vivo characterizations. Methods: Carboxylated fullerene was converted into acetylated fullerene and quercetin was conjugated and physically adsorbed on acetylated fullerene. Results: The particle size and zeta potential of QFC and chitosan-coated QFC (CC-QFC) were found to be 179.2 +/- 1.10, 293.4 +/- 2.757, -5.28 +/- 1.43 and 11.6 +/- 0.4 respectively. The entrapment efficiency, loading efficiency of QFC were found to be 85.55% and 42.77%. The MTT assay revealed 80.69% SH-SY5Y cell viability at a concentration of 50 mu g/ml. CC-QFC showed remarkable (89.20%) ex vivo mucoadhesive properties compared with QFC (66.67%). Further study showed no significant ciliotoxicity by CC-QFC. Conclusion: The obtained results suggested the potential of CC-QFC for treatment in Alzheimer's disease.

引用

页码：545 / 559

页数：15

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