Recent advances in the role of hydrogen sulfide in age-related diseases

被引：1
|
作者：
Zhang, Chao-Jing [1 ,2 ]
Wang, Yan [1 ,2 ]
Jin, Yu-Qing [1 ,2 ]
Zhu, Yi-Wen [1 ,2 ]
Zhu, Shuai-Gang [1 ,2 ]
Wang, Qi-Meng [1 ,2 ]
Jing, Mi-Rong [1 ,2 ]
Zhang, Yan-Xia [1 ,2 ]
Cai, Chun-Bo [1 ,2 ]
Feng, Zhi-Fen [3 ]
Ji, Xin-Ying [1 ,2 ,4 ]
Wu, Dong-Dong [1 ,2 ,5 ]
机构：
[1] Henan Univ, Sch Basic Med Sci, Sch Stomatol, Henan Int Joint Lab Nucl Prot Regulat, Kaifeng 475004, Henan, Peoples R China
[2] Henan Univ, Sch Basic Med Sci, Kaifeng Municipal Key Lab Cell Signal Transduct, Kaifeng 475004, Henan, Peoples R China
[3] Henan Univ, Sch Nursing & Hlth, Kaifeng 475004, Henan, Peoples R China
[4] Shu Qing Med Coll Zhengzhou, Fac Basic Med Subjects, Zhengzhou 450064, Henan, Peoples R China
[5] Henan Univ, Huaihe Hosp, Sch Stomatol, Dept Stomatol, Kaifeng 475004, Henan, Peoples R China
来源：
EXPERIMENTAL CELL RESEARCH | 2024年 / 441卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Hydrogen sulfide; Age-related diseases; Neurodegenerative diseases; Diabetes; Cancer; CYSTATHIONINE-BETA-SYNTHASE; LOWERS BLOOD-PRESSURE; FATTY LIVER-DISEASE; GAMMA-LYASE; OXIDATIVE STRESS; CHONDROCYTE APOPTOSIS; CELL-PROLIFERATION; SIGNALING MOLECULE; KIDNEY-DISEASE; NITRIC-OXIDE;
D O I：
10.1016/j.yexcr.2024.114172
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In recent years, the impact of age-related diseases on human health has become increasingly severe, and developing effective drugs to deal with these diseases has become an urgent task. Considering the essential regulatory role of hydrogen sulfide (H2S) in these diseases, it is regarded as a promising target for treatment. H2S is a novel gaseous transmitter involved in many critical physiological activities, including anti-oxidation, antiinflammation, and angiogenesis. H2S also regulates cell activities such as cell proliferation, migration, invasion, apoptosis, and autophagy. These regulatory effects of H2S contribute to relieving and treating age-related diseases. In this review, we mainly focus on the pathogenesis and treatment prospects of H2S in regulating agerelated diseases.
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页数：13
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