Cystatin C as a Marker of Kidney Function in Children

被引:0
作者
Skidmore, Megan [1 ]
Spencer, Sebastian [1 ,2 ,3 ]
Desborough, Robert [1 ,3 ]
Kent, David [1 ,4 ]
Bhandari, Sunil [1 ,3 ]
机构
[1] Hull York Med Sch, Fac Med, Kingston Upon Hull HU6 7RU, England
[2] Univ Hull, Sch Med Sci, Kingston Upon Hull HU6 7RX, England
[3] Hull Univ Teaching Hosp NHS Trust, Acad Renal Res, Kingston Upon Hull HU3 2JZ, England
[4] Leeds Teaching Hosp NHS Trust, Leeds Gen Infirm, Paediat Dept, Leeds LS1 3EX, England
关键词
acute kidney injury; biomarker; chronic kidney disease; estimated glomerular filtrate rate; paediatric; urinary tract malformations; GLOMERULAR-FILTRATION-RATE; SERUM CONCENTRATION; AGE; GFR; CREATININE; EQUATIONS; DISEASE; INFANTS; FORMULA; INJURY;
D O I
10.3390/biom14080938
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This review examines the reliability of cystatin C as a biomarker for kidney function in paediatric populations. Chronic kidney disease (CKD) affects a significant number of children globally, leading to severe health complications such as anaemia, hypertension, and growth disorders. Traditionally, kidney function has been assessed using the estimated glomerular filtration rate derived from serum creatinine, though this method is flawed due to variability in muscle mass, age, gender, and diet. Cystatin C offers an alternative as it is less influenced by these factors. Evidence from various studies indicates that cystatin C provides a more accurate assessment of kidney function, especially in neonates and children with urinary tract malformations. Additionally, it is more reliable in early detection of acute kidney injury in paediatric intensive care units. Despite its potential, cystatin C is not yet widely adopted in clinical guidelines, primarily due to a lack of large-scale paediatric studies. Nonetheless, existing research supports its utility in providing a consistent and precise measure of kidney function across different paediatric age groups, suggesting that it could enhance early diagnosis and management of CKD in children if more extensive validation studies are conducted.
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页数:11
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