Temporal dynamics of woolly mammoth genome erosion prior to extinction

被引：8

作者：

Dehasque, Marianne ^{[1
,2
,3
]}

Morales, Hernan E. ^{[4
]}

Diez-del-Molino, David ^{[1
,2
,3
]}

Pecnerova, Patricia ^{[2
,3
,5
]}

Chacon-Duque, J. Camilo ^{[1
,3
,6
]}

Kanellidou, Foteini ^{[1
,3
]}

Muller, Heloise ^{[7
]}

Plotnikov, Valerii ^{[8
]}

Protopopov, Albert ^{[8
]}

Tikhonov, Alexei ^{[9
]}

Nikolskiy, Pavel ^{[10
]}

Danilov, Gleb K. ^{[11
]}

Gianni, Maddalena ^{[12
,13
]}

van der Sluis, Laura ^{[12
,13
]}

Higham, Tom ^{[12
,13
]}

Heintzman, Peter D. ^{[1
,14
]}

Oskolkov, Nikolay ^{[15
]}

Gilbert, M. Thomas P. ^{[4
,16
]}

Gotherstrom, Anders ^{[1
,6
]}

van der Valk, Tom ^{[1
,2
,17
]}

Vartanyan, Sergey ^{[18
]}

Dalen, Love ^{[1
,2
,3
]}

机构：

[1] Ctr Palaeogenet, Svante Arrhenius Vag 20C, S-10691 Stockholm, Sweden

[2] Swedish Museum Nat Hist, Dept Bioinformat & Genet, Box 50007, S-10405 Stockholm, Sweden

[3] Stockholm Univ, Dept Zool, S-10691 Stockholm, Sweden

[4] Univ Copenhagen, Globe Inst, Ctr Evolutionary Hologen, Copenhagen, Denmark

[5] Univ Copenhagen, Dept Biol, Sect Computat & RNA Biol, DK-2200 Copenhagen, Denmark

[6] Stockholm Univ, Dept Archaeol & Class Studies, Lilla Frescativagen 7, S-11418 Stockholm, Sweden

[7] Univ Lyon, Univ Claude Bernard Lyon I, Ecole Normale Super Lyon, Biol, F-69007 Lyon, France

[8] Acad Sci Sakha Republ, Lenin Ave 33, Yakutsk, Republic Of Sak, Russia

[9] Russian Acad Sci, Zool Inst, St Petersburg, Russia

[10] Russian Acad Sci, Geol Inst, Moscow, Russia

[11] Russian Acad Sci, Peter Great Museum Anthropol & Ethnog, 3 Univ Embankment,Box 199034, St Petersburg, Russia

[12] Univ Vienna, Fac Life Sci, Dept Evolutionary Anthropol, Vienna, Austria

[13] Univ Vienna, Human Evolut & Archaeol Sci HEAS, Vienna, Austria

[14] Stockholm Univ, Dept Geol Sci, S-10691 Stockholm, Sweden

[15] Lund Univ, Dept Biol, Sci Life Lab, Natl Bioinformat Infrastruct Sweden, Lund, Sweden

[16] NTNU, Univ Museum, Trondheim, Norway

[17] SciLifeLab, Stockholm, Sweden

[18] Russian Acad Sci, North East Interdisciplinary Sci Res Inst NANA Shi, Far East Branch, Magadan, Russia

来源：

CELL | 2024年 / 187卷 / 14期

基金：

瑞典研究理事会; 欧洲研究理事会;

关键词：

INBREEDING DEPRESSION; MAMMUTHUS-PRIMIGENIUS; MITOCHONDRIAL GENOME; POPULATION HISTORY; SOCIAL-STRUCTURE; PLEISTOCENE; MUTATION; HOMOZYGOSITY; EVOLUTION; RUNS;

D O I：

10.1016/j.cell.2024.05.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A number of species have recently recovered from near-extinction. Although these species have avoided the immediate extinction threat, their long-term viability remains precarious due to the potential genetic consequences of population declines, which are poorly understood on a timescale beyond a few generations. Woolly mammoths ( Mammuthus primigenius ) became isolated on Wrangel Island around 10,000 years ago and persisted for over 200 generations before becoming extinct around 4,000 years ago. To study the evolutionary processes leading up to the mammoths' extinction, we analyzed 21 Siberian woolly mammoth genomes. Our results show that the population recovered quickly from a severe bottleneck and remained demographically stable during the ensuing six millennia. We find that mildly deleterious mutations gradually accumulated, whereas highly deleterious mutations were purged, suggesting ongoing inbreeding depression that lasted for hundreds of generations. The time-lag between demographic and genetic recovery has wide-ranging implications for conservation management of recently bottlenecked populations.

引用

页码：3531 / 3540.e13

页数：24

共 89 条

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