Effects of Propolis Consumption on Glycemic Indices and Liver Enzymes in Adults: A Grading of Recommendations Assessment, Development, and Valuation-assessed Systematic Review and Dose-Response Meta-analysis

被引:0
作者
Adeli, Shaghayegh [1 ]
Maroofi, Mahsa [2 ]
Tabrizi, Fatemeh Pourteymour Fard [3 ]
Alipour, Beitullah [3 ]
Heidari, Marzieh [1 ]
Vajdi, Mahdi [4 ]
Abbasalizad-Farhangi, Mahdieh [5 ]
机构
[1] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Biochem & Diet Therapy, Tabriz, Iran
[2] Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran
[3] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Community Nutr, Tabriz, Iran
[4] Isfahan Univ Med Sci, Dept Community Nutr, Sch Nutr & Food Sci, Esfahan, Iran
[5] Tabriz Univ Med Sci, Tabriz Hlth Serv Management Res Ctr, Tabriz, Iran
关键词
Glycemic indices; Liver enzymes; Meta-analysis; Propolis; Supplement; TYPE-2; DIABETES-MELLITUS; DOUBLE-BLIND; SUPPLEMENTATION; INFLAMMATION; DISEASE; BIAS; PUBLICATION; PREVALENCE; GLUCOSE; MODEL;
D O I
10.1016/j.clinthera.2024.06.022
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Purpose: Even though various randomized controlled trials (RCTs) have assessed the effect of propolis on glycemic indices and liver enzyme concentrations in adults, results have been inconsistent, without conclusive evidence. This systematic review and meta-analysis of RCTs sought to evaluate the effects of propolis consumption on glycemic indices and liver enzymes, fasting blood glucose, insulin, homeostatic model assessment of insulin resistance, glycosylated hemoglobin, alanine transaminase, aspartate aminotransferase, and gamma-glutamyl transferase in adults. Methods: Two independent researchers systematically searched PubMed, EMBASE, Scopus, Web of Science, and the Cochrane Library for English-language RCTs published up to April 2024. The results were generated through a random-effects model and presented as the weighted mean difference (WMD) with a 95% CI. The Cochrane Risk of Bias Tool for RCTs and Grading of Recommendations Assessment, Development, and Evaluation assessment were used to evaluate quality assessment and certainty of evidence. Findings: A total of 21 RCTs were included. A pooled analysis of 24 trials reported that propolis consumption led to a significant reduction in fasting blood glucose (WMD, - 9.75 mg/dL; 95% CI, - 16.14 to - 3.35), insulin (WMD, - 1.64 mu U/mL; 95% CI, - 2.61 to - 0.68), glycosylated hemoglobin (WMD, - 0.46%; 95% CI, - 0.71 to - 0.21), homeostatic model assessment of insulin resistance (WMD, - 0.54; 95% CI, - 0.98 to - 0.09), alanine transaminase (WMD, - 2.60 IU/L; 95% CI, - 4.58 to - 0.61), and aspartate aminotransferase (WMD, - 2.07 IU/L; 95% CI, - 3.05 to - 1.09). However, there were no significant effects on gamma-glutamyl transferase in comparison with the control group. Implications: This meta-analysis has shown that propolis supplementation may have beneficial effects on glycemic indices and liver enzymes. Future high-quality, long-term RCTs are needed to confirm our results. (c) 2024ElsevierHSJournals,Inc.
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收藏
页码:e6 / e14
页数:9
相关论文
共 67 条
[1]   The effects of propolis supplementation on high-sensitivity C-reactive protein, testosterone hormone, and metabolic profile in women with polycystic ovary syndrome: A randomized, triple-blinded, placebo-controlled clinical trial [J].
Abbasi, Elahe ;
Bagherniya, Mohammad ;
Soleimani, Davood ;
Ghasemi-Tehrani, Hatav ;
Abbaspour, Mohammadreza ;
Clark, Cain C. T. ;
Askari, Gholamreza .
PHYTOTHERAPY RESEARCH, 2023, 37 (11) :5366-5377
[2]  
Afsharpour F., 2017, J. Nutr. Sci. Diet., P9, DOI DOI 10.5812/JJNPP.102469
[3]   Changes in Lipid Profile, Liver Enzymes and Inflammatory Factors Following Oral Supplementation with Propolis in Patients with Type 2 Diabetes [J].
Afsharpour, Fatemeh ;
Javadi, Maryam ;
Hashemipour, Sima ;
Koushan, Yaghob ;
Haghighian, Hossein Khadem .
CLINICAL DIABETOLOGY, 2022, 11 (04) :224-231
[4]   Propolis supplementation improves glycemic and antioxidant status in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled study [J].
Afsharpour, Fatemeh ;
Javadi, Maryam ;
Hashemipour, Sima ;
Koushan, Yaghob ;
Haghighian, Hossein Khadem .
COMPLEMENTARY THERAPIES IN MEDICINE, 2019, 43 :283-288
[5]  
Akiyode Oluwaranti F, 2017, J Pharm Pract, V30, P238, DOI 10.1177/0897190015594732
[6]   Glycemic control and anti-osteopathic effect of propolis in diabetic rats [J].
Al-Hariri, M. ;
Eldin, T. Gamal ;
Abu-Hozaifa, B. ;
Elnour, A. .
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY, 2011, 4 :377-384
[7]   Effects of Bee Propolis on FBG, HbA1c, and Insulin Resistance in Healthy Volunteers [J].
Alassaf, Fawaz A. ;
Jasim, Mahmood H. M. ;
Alfahad, Mohanad ;
Qazzaz, Mohannad E. ;
Abed, Mohammed N. ;
Thanoon, Imad A-J .
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, 2021, 18 (04) :405-409
[8]   The effects of propolis on pro-oxidant-antioxidant balance, glycemic control, and quality of life in chronic kidney disease: a randomized, double-blind, placebo-controlled trial [J].
Anvarifard, Paniz ;
Ostadrahimi, Alireza ;
Ardalan, Mohammadreza ;
Anbari, Maryam ;
Ghoreishi, Zohreh .
SCIENTIFIC REPORTS, 2023, 13 (01)
[9]   NF-κB, Inflammation, and Metabolic Disease [J].
Baker, Rebecca G. ;
Hayden, Matthew S. ;
Ghosh, Sankar .
CELL METABOLISM, 2011, 13 (01) :11-22
[10]   GRADE guidelines: 3. Rating the quality of evidence [J].
Balshem, Howard ;
Helfand, Mark ;
Schuenemann, Holger J. ;
Oxman, Andrew D. ;
Kunz, Regina ;
Brozek, Jan ;
Vist, Gunn E. ;
Falck-Ytter, Yngve ;
Meerpohl, Joerg ;
Norris, Susan ;
Guyatt, Gordon H. .
JOURNAL OF CLINICAL EPIDEMIOLOGY, 2011, 64 (04) :401-406