Pembrolizumab and radiation therapy for multifocal myxofibrosarcoma of the scalp: a case report

被引：0

作者：

Grant, Christopher Ryan ^{[1
]}

Arter, Zhaohui ^{[2
]}

Smith, Janellen ^{[3
]}

Seyedin, Steven N. ^{[4
]}

Nourbakhsh, Mahra ^{[5
]}

Lee, Bonnie ^{[3
,5
]}

Creadore, Andrew ^{[3
]}

Mar, Nataliya ^{[2
]}

机构：

[1] Univ Calif Irvine, Med Ctr, Dept Med, 101 City Dr South, Orange, CA 92868 USA

[2] Univ Calif Irvine, Med Ctr, Div Hematol Oncol, Orange, CA USA

[3] Univ Calif Irvine, Med Ctr, Dept Dermatol, Orange, CA USA

[4] Univ Calif Irvine, Med Ctr, Dept Radiat Oncol, Orange, CA USA

[5] Univ Calif Irvine, Med Ctr, Dept Pathol, Orange, CA USA

来源：

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY | 2024年 / 16卷

关键词：

immune checkpoint inhibitor; myxofibrosarcoma; pembrolizumab; soft tissue sarcoma; SOFT-TISSUE SARCOMA; OPEN-LABEL; MULTICENTER; IMMUNOTHERAPY; CHEMOTHERAPY; PAZOPANIB; CANCER; GRADE;

D O I：

10.1177/17588359241259451

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Myxofibrosarcoma is one of the most common types of soft tissue sarcomas occurring in the lower limbs of male older adults. Mainstay treatment is surgical intervention with chemoradiotherapy with a combination of doxorubicin and ifosfamide with brachytherapy if advanced or metastatic. There are no guidelines on the combination of immunotherapy with radiation therapy for myxofibrosarcoma. We report the first documented case of unresectable multifocal myxofibrosarcoma that was treated with pembrolizumab and radiation therapy for first-line therapy with a significant response. We also highlight genomic markers and immune radiation priming therapy, forecasting favorable response in treatment with pembrolizumab.

引用

页数：9

共 42 条

[1]

[Anonymous], 2022, Sarcoma & GIST plus CUP | OncologyPRO

[2]

[Anonymous], Study Details | ENVASARC: envafolimab and envafolimab with ipilimumab in patients with undifferentiated pleomorphic sarcoma or myxofibrosarcoma

[3]

[Anonymous], 2013, Pathology and genetics of tumours of soft tissue and bone

[4] DNA mismatch repair in cancer [J].

Baretti, Marina ;

Le, Dung T. .

PHARMACOLOGY & THERAPEUTICS, 2018, 189 :45-62

[5] Immunotherapy with Single Agent Nivolumab for Advanced Leiomyosarcoma of the Uterus: Results of a Phase 2 Study [J].

Ben-Ami, Eytan ;

Barysauskas, Constance M. ;

Solomon, Sarah ;

Tahlil, Kadija ;

Malley, Rita ;

Hohos, Melissa ;

Polson, Kathleen ;

Loucks, Margaret ;

Severgnini, Mariano ;

Patel, Tara ;

Cunningham, Amy ;

Rodig, Scott J. ;

Hodi, F. Stephen ;

Morgan, Jeffrey A. ;

Merriam, Priscilla ;

Wagner, Andrew J. ;

Shapiro, Geoffrey I. ;

George, Suzanne .

CANCER, 2017, 123 (17) :3285-3290

[6]

Brennan MF., 2016, Management of soft tissue sarcoma, P143, DOI [10.1007/978-3-319-41906-0_7, DOI 10.1007/978-3-319-41906-0_7]

[7] The Effect of Concurrent Stereotactic Body Radiation and Anti-PD-1 Therapy for Recurrent Metastatic Sarcoma [J].

Callaghan, Cameron M. ;

Seyedin, Steven N. ;

Mohiuddin, Imran H. ;

Hawkes, Kelli L. ;

Petronek, Michael S. ;

Anderson, Carryn M. ;

Buatti, John M. ;

Milhem, Mohammed M. ;

Monga, Varun ;

Allen, Bryan G. .

RADIATION RESEARCH, 2020, 194 (02) :124-132

[8]

Chowdhary A., Cureus J Med Sci

[9] Activity of anthracycline- and ifosfamide-based chemotherapy in a series of patients affected by advanced myxofibrosarcoma [J].

Colia, Vittoria ;

Fiore, Marco ;

Provenzano, Salvatore ;

Fumagalli, Elena ;

Bertulli, Rossella ;

Morosi, Carlo ;

Dei Tos, Angelo P. ;

Barisella, Marta ;

Gronchi, Alessandro ;

Casali, Paolo G. ;

Sanfilippo, Roberta .

CLINICAL SARCOMA RESEARCH, 2017, 7

[10] Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial [J].

Demetri, George D. ;

von Mehren, Margaret ;

Jones, Robin L. ;

Hensley, Martee L. ;

Schuetze, Scott M. ;

Staddon, Arthur ;

Milhem, Mohammed ;

Elias, Anthony ;

Ganjoo, Kristen ;

Tawbi, Hussein ;

Van Tine, Brian A. ;

Spira, Alexander ;

Dean, Andrew ;

Khokhar, Nushmia Z. ;

Park, Youn Choi ;

Knoblauch, Roland E. ;

Parekh, Trilok V. ;

Maki, Robert G. ;

Patel, Shreyaskumar R. .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (08) :786-+

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