Large-scale study of blood markers in equine atypical myopathy reveals subclinical poisoning and advances in diagnostic and prognostic criteria

被引：5

作者：

Renaud, Benoit ^{[1
]}

Kruse, Caroline-J. ^{[2
]}

Francois, Anne-Christine ^{[1
]}

Cesarini, Carla ^{[3
]}

van Loon, Gunther ^{[4
]}

Palmers, Katrien ^{[5
]}

Boemer, Francois ^{[6
]}

Luis, Geraldine ^{[6
]}

Gustin, Pascal ^{[1
]}

Votion, Dominique-Marie ^{[1
]}

机构：

[1] Univ Liege, Fac Vet Med Pharmacol & Toxicol, Dept Funct Sci, Fundamental & Appl Res Anim & Hlth FARAH, B-4000 Liege 1, Sart Tilman, Belgium

[2] Univ Liege, Fac Vet Med Physiol & Sport Med, Dept Funct Sci, Fundamental & Appl Res Anim & Hlth FARAH, B-4000 Liege 1, Sart Tilman, Belgium

[3] Univ Liege, Fac Vet Med, Equine Clin Dept, Bat B41, B-4000 Liege, Sart Tilman, Belgium

[4] Univ Ghent, Fac Vet Med, Dept Internal Med Reprod & Populat Med, B-9820 Ghent, Belgium

[5] De Morette Equine Clin, B-1730 Asse, Belgium

[6] Univ Liege, CHU Sart Tilman, Biochem Genet Lab, B-4000 Liege 1, Sart Tilman, Belgium

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2024年 / 110卷

关键词：

Hypoglycin A; Methylenecyclopropylacetyl-carnitine; Toxin; Poisoning; Equids; Equine atypical myopathy; Acylcarnitines; Sapindaceae; COA DEHYDROGENASE-DEFICIENCY; EUROPEAN OUTBREAKS; HYPOGLYCIN; HORSES; ACID; HISTORY; SERUM; MADD;

D O I：

10.1016/j.etap.2024.104515

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Equine atypical myopathy (AM) is a severe rhabdomyolysis syndrome primarily caused by hypoglycin A (HGA) and methylenecyclopropylglycine protoxins. This study aimed to refine diagnostic and prognostic criteria for AM while exploring apparently healthy cograzers. Blood samples from 263 horses, including AM cases (n= 95), cograzers (n= 73), colic horses (n= 19), and controls (n= 76), were analyzed for HGA, its toxic metabolite, and acylcarnitines profile. Diseased horses exhibited alterations in acylcarnitines that strongly distinguished them from controls and colic horses. Regression analyses identified distinct acylcarnitines profiles among groups, with cograzers showing intermediate alterations. Age and gelding status emerged as protective factors against AM. Furthermore, serum acylcarnitines profiling was valuable in predicting AM survival, with isovaleryl-/2-methylbutyrylcarnitine (i.e., C5 acylcarnitine) showing promise as both a diagnostic and prognostic marker. Subclinical alterations in cograzers underscore a novel aspect: the presence of subclinical cases of AM.

引用

页数：15

共 40 条

[1] Samaras and seedlings of Acer pseudoplatanus are potential sources of hypoglycin A intoxication in atypical myopathy without necessarily inducing clinical signs [J].

Baise, E. ;

Habyarimana, J. A. ;

Amory, H. ;

Boemer, F. ;

Douny, C. ;

Gustin, P. ;

Marcillaud-Pitel, C. ;

Patarin, F. ;

Weber, M. ;

Votion, D. -M. .

EQUINE VETERINARY JOURNAL, 2016, 48 (04) :414-417

[2] Predictive value of hypoglycin A and methylencyclopropylacetic acid conjugates in a horse with atypical myopathy in comparison to its cograzing partners [J].

Bochnia, M. ;

Scheidemann, W. ;

Ziegler, J. ;

Sander, J. ;

Vollstedt, S. ;

Glatter, M. ;

Janzen, N. ;

Terhardt, M. ;

Zeyner, A. .

EQUINE VETERINARY EDUCATION, 2018, 30 (01) :24-28

[3] Hypoglycin A Content in Blood and Urine Discriminates Horses with Atypical Myopathy from Clinically Normal Horses Grazing on the Same Pasture [J].

Bochnia, M. ;

Ziegler, J. ;

Sander, J. ;

Uhlig, A. ;

Schaefer, S. ;

Vollstedt, S. ;

Glatter, M. ;

Abel, S. ;

Recknagel, S. ;

Schusser, G. F. ;

Wensch-Dorendorf, M. ;

Zeyner, A. .

PLOS ONE, 2015, 10 (09)

[4] Detection of MCPG metabolites in horses with atypical myopathy [J].

Bochnia, Mandy ;

Sander, Johannes ;

Ziegler, Joerg ;

Terhardt, Michael ;

Sander, Stefanie ;

Janzen, Nils ;

Cavalleri, Jessika-M. V. ;

Zuraw, Aleksandra ;

Wensch-Dorendorf, Monika ;

Zeyner, Annette .

PLOS ONE, 2019, 14 (02)

[5] Acylcarnitines profile best predicts survival in horses with atypical myopathy [J].

Boemer, Francois ;

Detilleux, Johann ;

Cello, Christophe ;

Amory, Helene ;

Marcillaud-Pitel, Christel ;

Richard, Eric ;

van Galen, Gaby ;

van Loon, Gunther ;

Lefere, Laurence ;

Votion, Dominique-Marie .

PLOS ONE, 2017, 12 (08)

[6] Quantification of hypoglycin A in serum using aTRAQ® assay [J].

Boemer, Francois ;

Deberg, Michelle ;

Schoos, Roland ;

Baise, Etienne ;

Amory, Helene ;

Gault, Gilbert ;

Carlier, Jeremy ;

Gaillard, Yvan ;

Marcillaud-Pitel, Christel ;

Votion, Dominique .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2015, 997 :75-80

[7] Neonatal blood carnitine concentrations: Normative data by electrospray tandem mass spectometry [J].

Chace, DH ;

Pons, R ;

Chiriboga, CA ;

McMahon, DJ ;

Tein, I ;

Naylor, EW ;

De Vivo, DC .

PEDIATRIC RESEARCH, 2003, 53 (05) :823-829

[8] Performance of some variable selection methods when multicollinearity is present [J].

Chong, IG ;

Jun, CH .

CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 2005, 78 (1-2) :103-112

[9] Atypical myopathy in the South-East of England: Clinicopathological data and outcome in hospitalised horses [J].

Dunkel, B. ;

Ryan, A. ;

Haggett, E. ;

Knowles, E. J. .

EQUINE VETERINARY EDUCATION, 2020, 32 (02) :90-95

[10] Equine atypical myopathy in the UK: Epidemiological characteristics of cases reported from 2011 to 2015 and factors associated with survival [J].

Gonzalez-Medina, S. ;

Ireland, J. L. ;

Piercy, R. J. ;

Newton, J. R. ;

Votion, D. M. .

EQUINE VETERINARY JOURNAL, 2017, 49 (06) :746-752

← 1 2 3 4 →