Continuous Glucose, Insulin and Lifestyle Data Augmentation in Artificial Pancreas Using Adaptive Generative and Discriminative Models

被引:1
|
作者
Kalita, Deepjyoti [1 ]
Sharma, Hrishita [1 ]
Mirza, Khalid B. [1 ]
机构
[1] Natl Inst Technol, Dept Bioetchnol & Med Engn, Rourkela 769008, India
关键词
Glucose; Insulin; Time series analysis; Sensors; Data models; Generative adversarial networks; Diabetes; Continuous glucose monitoring; data augmentation; discriminative score; generative adversarial network; predictive scores; TimeGAN;
D O I
10.1109/JBHI.2024.3396880
中图分类号
TP [自动化技术、计算机技术];
学科分类号
0812 ;
摘要
Artificial pancreas requires data from multiple sources for accurate insulin dose estimation. These include data from continuous glucose sensors, past insulin dosage information, meal quantity and time and physical activity data. The effectiveness of closed-loop diabetes management systems might be hampered by the absence of these data caused by device error or lack of compliance by patients. In this study, we demonstrate the effect of output sequence length-driven generative and discriminative model selection in high quality data generation and augmentation. This novel generative adversarial network (GAN) based architecture automatically selects the generator and discriminator architecture based on the desired output sequence length. The proposed model is able to generate glucose, physical activity, meal information data for individual patients. The discriminative scores for Ohio T1DM (2018) dataset were 0.17 +/- 0.03 (Inputs: CGM, CHO, Insulin) and 0.15$ +/- 0.02 (Inputs: CGM, CHO, Insulin, Heart Rate, Steps) and for Ohio T1D (2020) dataset was 0.16 +/- 0.02 (Inputs: CGM, CHO, Insulin) and 0.15 +/- 0.02 (Inputs: CGM, CHO, Insulin, acceleration). A mixture of generated and real data was used to test predictive scores for glucose forecasting models. The best RMSE and MARD achieved for OhioT1DM patients were 17.19 +/- 3.22 and 7.14 +/- 1.76 for PH=30 min with CGM, CHO, Insulin, heartrate and steps as inputs. Similarly, the RMSE and MARD for real+synthetic data were 15.63 +/- 2.57 and 5.86 +/- 1.69 respectively. Compared to existing generative models, we demonstrate that sequence length based architecture selection leads to better synthetic data generation for multiple output sequences (CGM, CHO, Insulin) and forecasting accuracy.
引用
收藏
页码:4963 / 4974
页数:12
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