A comprehensive investigation of the associations between tensor-based morphometry indices and executive functions, memory, language, and visuospatial abilities in patients in the Alzheimer's disease continuum

被引：0

作者：

Jahromi, Sahba Azadikhah ^{[1
]}

Parhizkar, Aram ^{[2
]}

Mohammadi, Mahtab ^{[3
]}

Kazemi, Danial ^{[4
]}

Tajik, Mohammad Hassan ^{[5
]}

Nazari, Maryam ^{[6
]}

Bemanalizadeh, Maryam ^{[7
,8
]}

Alavi, Seyed Mohammad Amin ^{[9
]}

机构：

[1] Iran Univ Sci & Technol IUST, Sch Mech Engn, Tehran, Iran

[2] Univ Padua, Dept Pharmaceut & Pharmacol Sci, Padua, Italy

[3] Islamic Azad Univ, Fac Psychol & Educ Sci, Dept Psychol, Cent Tehran Branch, Tehran, Iran

[4] Isfahan Univ Med Sci, Student Res Comm, Hezar Jerib St, Esfahan, Iran

[5] Univ Tehran Med Sci, Dept Anat, Tehran, Iran

[6] Islamic Azad Univ Tehran IAUTMU, Med Branch, Tehran, Iran

[7] Univ Tehran Med Sci, Students Sci Res Ctr, NeuroTRACT Assoc, Tehran, Iran

[8] Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Esfahan, Iran

[9] Ahvaz Jundishapur Univ Med Sci, Fac Med, Golestan Blvd, Ahvaz 6135715794, Khuzestan, Iran

来源：

CLINICAL NEUROLOGY AND NEUROSURGERY | 2024年 / 246卷

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

Alzheimer's Disease; Cognition; Language; Memory; Tensor-Based Morphometry (TBM); MILD COGNITIVE IMPAIRMENT; COMPOSITE SCORE; BRAIN; DEMENTIA; ADNI; MRI; RATES; LINE; TOOL;

D O I：

10.1016/j.clineuro.2024.108542

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objectives: Based on the literature, tensor-based morphometry (TBM) parameters were related to neurocognitive functions such as memory, learning, language ability, and executive functions. The present study aims to evaluate the associations between TBM indices with executive functions, memory, language, and visuospatial abilities and the value of TBM in the clinical diagnosis of Alzheimer's disease (AD) among individuals with Alzheimer's disease continuum and mild cognitive impairment (MCI) from Alzheimer's Disease Neuroimaging Initiative (ADNI). Methods: The authors used ADNI-memory (ADNI-MEM), ADNI-executive functions (ADNI-EF), ADNI-language (ADNI-LAN), and ADNI-visuospatial (ADNI-VS) composite scores. TBM parameters, including measure 1, which represents average within a statistically defined region-of-interest inside the temporal lobes and measure 2 which indicates average within an anatomically defined region-of-interest including bilateral temporal lobes were utilized in the current study. Statistical analysis was performed using IBM SPSS Statistics version 26, and Pearson's correlation, Bonferroni's correction, and multiple linear regression were utilized for data analysis. P <0.05 was considered statistically significant. Results: After screening 800 participants, 270 (151 men, 119 women) were selected for a study with TBM scores and cognition-related assessments at 6, 12, and 24 months. Groups included healthy controls (n=53), =53), MCI (n=158), =158), and Alzheimer's Disease (AD) (n=59). =59). TBM indices correlated with cognitive scores in MCI and AD groups but not healthy controls. Changes in TBM indices and cognitive scores were significantly correlated in MCI and AD groups over 24 months. TBM indices were weak predictors of cognitive decline at all time points. Conclusions: TBM can help physicians diagnose MCI and AD early. However, TBM could not strongly predict cognitive functions decline at all time points.

引用

页数：9