Glial cells in the mammalian olfactory bulb

被引:1
|
作者
Zhao, Dan [1 ]
Hu, Meigeng [1 ]
Liu, Shaolin [1 ]
机构
[1] Univ Georgia, Isakson Ctr Neurol Dis Res, Dept Physiol & Pharmacol, Dept Biomed Sci,Coll Vet Med, Athens, GA 30602 USA
关键词
olfactory bulb; glial cells; function; interaction; neurodegeneration; CENTRAL-NERVOUS-SYSTEM; NEURAL STEM-CELLS; FIBRILLARY ACIDIC PROTEIN; ROSTRAL MIGRATORY STREAM; GROWTH-FACTOR RECEPTOR; RECTIFYING K+ CHANNEL; MICROGLIA CROSS-TALK; ENSHEATHING CELLS; RADIAL GLIA; SUBVENTRICULAR ZONE;
D O I
10.3389/fncel.2024.1426094
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The mammalian olfactory bulb (OB), an essential part of the olfactory system, plays a critical role in odor detection and neural processing. Historically, research has predominantly focused on the neuronal components of the OB, often overlooking the vital contributions of glial cells. Recent advancements, however, underscore the significant roles that glial cells play within this intricate neural structure. This review discus the diverse functions and dynamics of glial cells in the mammalian OB, mainly focused on astrocytes, microglia, oligodendrocytes, olfactory ensheathing cells, and radial glia cells. Each type of glial contributes uniquely to the OB's functionality, influencing everything from synaptic modulation and neuronal survival to immune defense and axonal guidance. The review features their roles in maintaining neural health, their involvement in neurodegenerative diseases, and their potential in therapeutic applications for neuroregeneration. By providing a comprehensive overview of glial cell types, their mechanisms, and interactions within the OB, this article aims to enhance our understanding of the olfactory system's complexity and the pivotal roles glial cells play in both health and disease.
引用
收藏
页数:28
相关论文
共 50 条
  • [1] Olfactory coding in the mammalian olfactory bulb
    Leon, M
    Johnson, BA
    BRAIN RESEARCH REVIEWS, 2003, 42 (01) : 23 - 32
  • [2] MELATONIN IN THE MAMMALIAN OLFACTORY BULB
    Corthell, J. T.
    Olcese, J.
    Trombley, P. Q.
    NEUROSCIENCE, 2014, 261 : 74 - 84
  • [3] P2 receptors in rat olfactory bulb glial cells
    Bobanovic, LK
    Murrell-Lagnado, RD
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 : 24 - 24
  • [4] Centrifugal innervation of the mammalian olfactory bulb
    Matsutani, Shinji
    Yamamoto, Noboru
    ANATOMICAL SCIENCE INTERNATIONAL, 2008, 83 (04) : 218 - 227
  • [5] Odor representations in the mammalian olfactory bulb
    Khan, Adil Ghani
    Parthasarathy, K.
    Bhalla, Upinder Singh
    WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE, 2010, 2 (05) : 603 - 611
  • [6] Development of the mammalian main olfactory bulb
    Tufo, Candida
    Poopalasundaram, Subathra
    Dorrego-Rivas, Ana
    Ford, Marc C.
    Graham, Anthony
    Grubb, Matthew S.
    DEVELOPMENT, 2022, 149 (03):
  • [7] FUNCTIONAL COMPARTMENTALIZATION IN THE MAMMALIAN OLFACTORY BULB
    Mori, Kensaku
    Lgarashi, Kei
    Matsumoto, Hideyuki
    Leki, Nao
    An, Myonho
    JOURNAL OF PHYSIOLOGICAL SCIENCES, 2009, 59 : 32 - 32
  • [8] SYNAPTIC ORGANIZATION OF MAMMALIAN OLFACTORY BULB
    SHEPHERD, GM
    PHYSIOLOGICAL REVIEWS, 1972, 52 (04) : 864 - +
  • [9] THE ELECTRICAL ACTIVITY OF THE MAMMALIAN OLFACTORY BULB
    ADRIAN, ED
    ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1950, 2 (04): : 377 - 388
  • [10] Centrifugal innervation of the mammalian olfactory bulb
    Shinji Matsutani
    Noboru Yamamoto
    Anatomical Science International, 2008, 83 : 218 - 227