Insulin Dynamics and Pathophysiology in Youth-Onset Type 2 Diabetes

被引：1
作者：
Abu-Nejem, Rozan [1 ,2 ]
Hannon, Tamara S. [1 ,2 ]
机构：
[1] Indiana Univ Sch Med, Dept Pediat, Div Pediat Endocrinol & Diabetol, Indianapolis, IN 46202 USA
[2] Indiana Univ Sch Med, Dept Pediat, Div Pediat Hlth Serv Res, Indianapolis, IN 46202 USA
来源：
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2024年 / 109卷 / 10期
关键词：
insulin resistance; beta cell dysfunction; hyperglycemia; prediabetes; adolescent; pediatric; BETA-CELL FUNCTION; ENDOPLASMIC-RETICULUM STRESS; IMPAIRED GLUCOSE-TOLERANCE; FATTY-ACID ELEVATION; RISK-FACTORS; AFRICAN-AMERICAN; OBESE YOUTH; VISCERAL ADIPOSITY; GLUCAGON-RELEASE; HEMOGLOBIN A1C;
D O I：
10.1210/clinem/dgae463
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Youth-onset type 2 diabetes (T2D) is increasing around the globe. The mounting disease burden of youth-onset T2D portends substantial consequences for the health outcomes of young people and for health care systems. The pathophysiology of this condition is characterized by insulin resistance and initial insulin hypersecretion +/- an inherent insulin secretory defect, with progressive loss of stimulated insulin secretion leading to pancreatic beta-cell failure. Research studies focusing on youth-onset T2D have illuminated key differences for youth- vs adult-onset T2D, with youth having more profound insulin resistance and quicker progression to loss of sufficient insulin secretion to maintain euglycemia. There is a need for therapies that are targeted to improve both insulin resistance and, importantly, maintain sufficient insulin secretory function over the lifespan in youth-onset T2D.
引用
收藏
页码：2411 / 2421
页数：11
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