Post-Traumatic Epilepsy: Observations from an Urban Level 1 Trauma Center

被引:0
|
作者
Kotas, Daniel [1 ]
Zhao, Huaqing [2 ,3 ]
Turella, John [3 ]
Kasoff, Willard S. [1 ]
机构
[1] Temple Univ, Lewis Katz Sch Med, Dept Neurosci, Philadelphia, PA 19140 USA
[2] Temple Univ, Lewis Katz Sch Med, Dept Biomed Educ & Data Sci, Philadelphia, PA 19140 USA
[3] Temple Univ, Ctr Biostat & Epidemiol, Lewis Katz Sch Med, Philadelphia, PA 19140 USA
来源
NEUROLOGY INTERNATIONAL | 2024年 / 16卷 / 04期
关键词
post-traumatic epilepsy; traumatic brain injury; follow-up; BRAIN-INJURY; RISK-FACTORS; HEAD-INJURY; EPIDEMIOLOGY; SEIZURES;
D O I
10.3390/neurolint16040063
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
There are approximately 2.5 million cases of traumatic brain injury (TBI) in the U.S. each year. Post-traumatic epilepsy (PTE), a sequela of TBI, has been shown to occur in approximately 15% of TBI patients. Pre-disposing risk factors for the development of PTE include severe TBI and penetrating head injury. PTE is associated with poor functional outcomes, increased negative social factors, and mental illness. We conducted a retrospective chart review with a 5-year timeframe at an urban Level 1 Trauma Center. Patients with ICD-10-CM codes associated with TBI were identified. Patients were coded as TBI with or without PTE by the presence of codes associated with PTE. Datapoints collected included risk factors for PTE and encounters with neurologists. A total of 1886 TBI patients were identified, with 178 (9.44%) classified as TBI with PTE. The most significant risk factor associated with PTE was severe brain injury, with an odds ratio (OR) of 2.955 (95% CI [2.062,4.236]; p < 0.0001). Only 19 of 178 patients (10.7%) visited a neurologist beyond 6 months after TBI. Our results suggest the presence of a significant population of patients with PTE and the need for better follow-up.
引用
收藏
页码:845 / 852
页数:8
相关论文
共 50 条
  • [41] Neuroinflammation in Post-Traumatic Epilepsy: Pathophysiology and Tractable Therapeutic Targets
    Sharma, Rishabh
    Leung, Wai Lam
    Zamani, Akram
    O'Brien, Terence J.
    Espinosa, Pablo M. Casillas
    Semple, Bridgette D.
    BRAIN SCIENCES, 2019, 9 (11)
  • [42] Post-Traumatic Epilepsy: Review of Risks, Pathophysiology, and Potential Biomarkers
    Lamar, Cory D.
    Hurley, Robin A.
    Rowland, Jared A.
    Taber, Katherine H.
    JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES, 2014, 26 (02) : 108 - 113
  • [43] Inflammasomes at the crossroads of traumatic brain injury and post-traumatic epilepsy
    Javalgekar, Mohit
    Jupp, Bianca
    Vivash, Lucy
    O'Brien, Terence J.
    Wright, David K.
    Jones, Nigel C.
    Ali, Idrish
    JOURNAL OF NEUROINFLAMMATION, 2024, 21 (01)
  • [44] A Comprehensive and Advanced Mouse Model of Post-Traumatic Epilepsy with Robust Spontaneous Recurrent Seizures
    Reddy, Doodipala Samba
    Golub, Victoria M.
    Ramakrishnan, Sreevidhya
    Abeygunaratne, Hasara
    Dowell, Samantha
    Wu, Xin
    CURRENT PROTOCOLS, 2022, 2 (06):
  • [45] In search of antiepileptogenic treatments for post-traumatic epilepsy
    Saletti, Patricia G.
    Ali, Idrish
    Casillas-Espinosa, Pablo M.
    Semple, Bridgette D.
    Lisgaras, Christos Panagiotis
    Moshe, Solomon L.
    Galanopoulou, Aristea S.
    NEUROBIOLOGY OF DISEASE, 2019, 123 : 86 - 99
  • [46] Genetic diversity drives extreme responses to traumatic brain injury and post-traumatic epilepsy
    Shannon, Tyler
    Cotter, Christopher
    Fitzgerald, Julie
    Houle, Samuel
    Levine, Noah
    Shen, Yuyan
    Rajjoub, Noora
    Dobres, Shannon
    Iyer, Sidharth
    Xenakis, James
    Lynch, Rachel
    Villena, Fernando Pardo-Manuel de
    Kokiko-Cochran, Olga
    Gu, Bin
    EXPERIMENTAL NEUROLOGY, 2024, 374
  • [47] Post-traumatic epilepsy: Insights from human cortical contused tissue☆
    Becerra-Hernandez, Lina, V
    Gonzalez-Acosta, Carlos A.
    Buritica-Ramirez, Efrain
    EPILEPSY & BEHAVIOR, 2025, 164
  • [48] Clinical characteristics of post-traumatic epilepsy and the factors affecting the latency of PTE
    Tingting Yu
    Xiao Liu
    Lei Sun
    Jianping Wu
    Qun Wang
    BMC Neurology, 21
  • [49] Incidence of post-traumatic epilepsy following paediatric traumatic brain injury: protocol for systematic review and meta-analysis
    Mariajoseph, Frederick P.
    Rewell, Sarah S.
    O'Brien, Terence J.
    Semple, Bridgette D.
    Antonic-Baker, Ana
    BMJ OPEN, 2021, 11 (11):
  • [50] Transcriptomic alterations in cortical astrocytes following the development of post-traumatic epilepsy
    Leonard, John
    Wei, Xiaoran
    Browning, Jack
    Gudenschwager-Basso, Erwin Kristobal
    Li, Jiangtao
    Harris, Elizabeth A.
    Olsen, Michelle L.
    Theus, Michelle H.
    SCIENTIFIC REPORTS, 2024, 14 (01)