Post-Traumatic Epilepsy: Observations from an Urban Level 1 Trauma Center

被引:0
|
作者
Kotas, Daniel [1 ]
Zhao, Huaqing [2 ,3 ]
Turella, John [3 ]
Kasoff, Willard S. [1 ]
机构
[1] Temple Univ, Lewis Katz Sch Med, Dept Neurosci, Philadelphia, PA 19140 USA
[2] Temple Univ, Lewis Katz Sch Med, Dept Biomed Educ & Data Sci, Philadelphia, PA 19140 USA
[3] Temple Univ, Ctr Biostat & Epidemiol, Lewis Katz Sch Med, Philadelphia, PA 19140 USA
来源
NEUROLOGY INTERNATIONAL | 2024年 / 16卷 / 04期
关键词
post-traumatic epilepsy; traumatic brain injury; follow-up; BRAIN-INJURY; RISK-FACTORS; HEAD-INJURY; EPIDEMIOLOGY; SEIZURES;
D O I
10.3390/neurolint16040063
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
There are approximately 2.5 million cases of traumatic brain injury (TBI) in the U.S. each year. Post-traumatic epilepsy (PTE), a sequela of TBI, has been shown to occur in approximately 15% of TBI patients. Pre-disposing risk factors for the development of PTE include severe TBI and penetrating head injury. PTE is associated with poor functional outcomes, increased negative social factors, and mental illness. We conducted a retrospective chart review with a 5-year timeframe at an urban Level 1 Trauma Center. Patients with ICD-10-CM codes associated with TBI were identified. Patients were coded as TBI with or without PTE by the presence of codes associated with PTE. Datapoints collected included risk factors for PTE and encounters with neurologists. A total of 1886 TBI patients were identified, with 178 (9.44%) classified as TBI with PTE. The most significant risk factor associated with PTE was severe brain injury, with an odds ratio (OR) of 2.955 (95% CI [2.062,4.236]; p < 0.0001). Only 19 of 178 patients (10.7%) visited a neurologist beyond 6 months after TBI. Our results suggest the presence of a significant population of patients with PTE and the need for better follow-up.
引用
收藏
页码:845 / 852
页数:8
相关论文
共 50 条
  • [21] Animal models of post-traumatic epilepsy
    Ostergard, Thomas
    Sweet, Jennifer
    Kusyk, Dorian
    Herring, Eric
    Miller, Jonathan
    JOURNAL OF NEUROSCIENCE METHODS, 2016, 272 : 50 - 55
  • [22] Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis
    Casillas-Espinosa, Pablo M.
    Andrade, Pedro
    Santana-Gomez, Cesar
    Paananen, Tomi
    Smith, Gregory
    Ali, Idrish
    Ciszek, Robert
    Ndode-Ekane, Xavier Ekolle
    Brady, Rhys D.
    Tohka, Jussi
    Hudson, Matthew R.
    Perucca, Piero
    Braine, Emma L.
    Immonen, Riikka
    Puhakka, Noora
    Shultz, Sandy R.
    Jones, Nigel C.
    Staba, Richard J.
    Pitkanen, Asia
    O'Brien, Terence J.
    EPILEPSY RESEARCH, 2019, 156
  • [23] Risk factors for post-traumatic epilepsy
    Khalili, Hosseinali
    Kashkooli, Nima Rahimi
    Niakan, Amin
    Asadi-Pooya, Ali A.
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2021, 89 : 81 - 84
  • [24] Predicting and Treating Post-traumatic Epilepsy
    Clio Rubinos
    Brandon Waters
    Lawrence J. Hirsch
    Current Treatment Options in Neurology, 2022, 24 : 365 - 381
  • [25] The Level of Neuregulin-1 after Traumatic Brain Injury and Formation of Post-Traumatic Epilepsy
    L. M. Gazaryan
    N. V. Selyanina
    Yu. V. Karakulova
    D. Yu. Sosnin
    Bulletin of Experimental Biology and Medicine, 2019, 167 : 207 - 209
  • [26] The Level of Neuregulin-1 after Traumatic Brain Injury and Formation of Post-Traumatic Epilepsy
    Gazaryan, L. M.
    Selyanina, N. V.
    Karakulova, Yu. V.
    Sosnin, D. Yu.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2019, 167 (02) : 207 - 209
  • [27] Insights into epileptogenesis from post-traumatic epilepsy
    Pease, Matthew
    Gupta, Kunal
    Moshe, Solomon L.
    Correa, Daniel J.
    Galanopoulou, Aristea S.
    Okonkwo, David O.
    Gonzalez-Martinez, Jorge
    Shutter, Lori
    Diaz-Arrastia, Ramon
    Castellano, James F.
    NATURE REVIEWS NEUROLOGY, 2024, 20 (05) : 298 - 312
  • [28] Knowledge atlas of post-traumatic epilepsy research: Based on citespace visualization analysis
    Zhan, Jingjing
    Ma, Yixun
    Zhao, Dong
    Li, Zheng
    Tan, Huachao
    Wang, Xu
    Liu, Hongxia
    Yang, Tiantong
    EPILEPSY RESEARCH, 2021, 178
  • [29] Results of phase II pharmacokinetic study of levetiracetam for prevention of post-traumatic epilepsy
    Klein, Pavel
    Herr, Daniel
    Pearl, Phillip L.
    Natale, JoAnne
    Levine, Zachary
    Nogay, Claude
    Sandoval, Fabian
    Trzcinsky, Stacey
    Atabaki, Shireen M.
    Tsuchida, Tammy
    van den Anker, John
    Soldin, Steven J.
    He, Jianping
    McCarter, Robert
    EPILEPSY & BEHAVIOR, 2012, 24 (04) : 457 - 461
  • [30] POST-TRAUMATIC EPILEPSY PROPHYLAXIS
    YOUNG, B
    RAPP, R
    BROOKS, WH
    MADAUSS, W
    NORTON, JA
    EPILEPSIA, 1979, 20 (06) : 671 - 681