Particulate matter 2.5 accelerates aging: Exploring cellular senescence and age-related diseases

被引：4

作者：

Wang, Sheng-nan ^{[1
]}

Shi, Yan-chuan ^{[2
,3
,4
]}

Lin, Shu ^{[2
,3
]}

He, He-fan ^{[1
]}

机构：

[1] Fujian Med Univ, Affiliated Hosp 2, Dept Anesthesiol, Quanzhou, Fujian, Peoples R China

[2] Fujian Med Univ, Affiliated Hosp 2, Ctr Neurol & Metab Res, Quanzhou, Fujian, Peoples R China

[3] Garvan Inst Med Res, Grp Neuroendocrinol, 384 Victoria St, Sydney, Australia

[4] UNSW, Fac Med, St Vincents Clin Sch, Sydney, Australia

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2024年 / 284卷

关键词：

Particulate matter 2.5; Aging; Cellular senescence; Age-related diseases; LONG-TERM EXPOSURE; AIR-POLLUTION EXPOSURE; POLYCYCLIC AROMATIC-HYDROCARBONS; OBSTRUCTIVE PULMONARY-DISEASE; ENDOPLASMIC-RETICULUM STRESS; SMALL EXTRACELLULAR VESICLES; GLOBAL DNA METHYLATION; HUMAN HEALTH IMPACT; OXIDATIVE STRESS; TELOMERE LENGTH;

D O I：

10.1016/j.ecoenv.2024.116920

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Exposure to Particulate matter 2.5 (PM2.5) accelerates aging, causing declines in tissue and organ function, and leading to diseases such as cardiovascular, neurodegenerative, and musculoskeletal disorders. PM2.5 is a major environmental pollutant and an exogenous pathogen in air pollution that is now recognized as an accelerator of human aging and a predisposing factor for several age-related diseases. In this paper, we seek to elucidate the mechanisms by which PM2.5 induces cellular senescence, such as genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, and mitochondrial dysfunction, and age-related diseases. Our goal is to increase awareness among researchers within the field of the toxicity of environmental pollutants and to advocate for personal and public health initiatives to curb their production and enhance population protection. Through these endeavors, we aim to promote longevity and health in older adults.

引用

页数：22

共 368 条

[1] In vitro short-term exposure to air pollution PM2.5-0.3 induced cell cycle alterations and genetic instability in a human lung cell coculture model [J].

Abbas, Imane ;

Verdin, Anthony ;

Escande, Fabienne ;

Saint-Georges, Francoise ;

Cazier, Fabrice ;

Mulliez, Philippe ;

Courcot, Dominique ;

Shirali, Pirouz ;

Gosset, Pierre ;

Garcon, Guillaume .

ENVIRONMENTAL RESEARCH, 2016, 147 :146-158

[2] Carnosine Supplementation Mitigates the Deleterious Effects of Particulate Matter Exposure in Mice [J].

Abplanalp, Wesley ;

Haberzettl, Petra ;

Bhatnagar, Aruni ;

Conklin, Daniel J. ;

O'Toole, Timothy E. .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2019, 8 (13)

[3] Association between exposure to fine particulate matter and osteoporosis: a population-based cohort study [J].

Adami, G. ;

Cattani, G. ;

Rossini, M. ;

Viapiana, O. ;

Olivi, P. ;

Orsolini, G. ;

Bertoldo, E. ;

Fracassi, E. ;

Gatti, D. ;

Fassio, A. .

OSTEOPOROSIS INTERNATIONAL, 2022, 33 (01) :169-176

[4] Connecting obesity, aging and diabetes [J].

Ahima, Rexford S. .

NATURE MEDICINE, 2009, 15 (09) :996-997

[5] Morphological, Mineralogical, and Biochemical Characteristics of Particulate Matter in Three Size Fractions (PM10, PM2.5, and PM1) in the Urban Environment [J].

Ahmad, Shafiq ;

Zeb, Bahadar ;

Ditta, Allah ;

Alam, Khan ;

Shahid, Umer ;

Shah, Atta Ullah ;

Ahmad, Iftikhar ;

Alasmari, Abdulrahman ;

Sakran, Mohamed ;

Alqurashi, Mohammed .

ACS OMEGA, 2023, 8 (35) :31661-31674

[6] NAFLD in the Elderly [J].

Alqahtani, Saleh A. ;

Schattenberg, Joern M. .

CLINICAL INTERVENTIONS IN AGING, 2021, 16 :1633-1649

[7] Inflammation response, oxidative stress and DNA damage caused by urban air pollution exposure increase in the lack of DNA repair XPC protein [J].

Alves, Nilmara de Oliveira ;

Pereira, Guilherme Martins ;

Di Domenico, Marlise ;

Costanzo, Giovanna ;

Benevenuto, Sarah ;

Fonoff, Adriana M. de Oliveira ;

Xavier Costa, Natalia de Souza ;

Ribeiro, Gabriel, Jr. ;

Kajitani, Gustavo Satoru ;

Moreno, Natalia Cestari ;

Fotoran, Wesley ;

Torres, Janaina Iannicelli ;

de Andrade, Jailson Bittencourt ;

Veras, Mariana Matera ;

Artaxo, Paulo ;

Martins Menck, Carlos Frederico ;

Vasconcellos, Perola de Castro ;

Saldiva, Paulo .

ENVIRONMENT INTERNATIONAL, 2020, 145

[8] Ambient PM2.5 Reduces Global and Regional Life Expectancy [J].

Apte, Joshua S. ;

Brauer, Michael ;

Cohen, Aaron J. ;

Ezzati, Majid ;

Pope, C. Arden, III .

ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS, 2018, 5 (09) :546-551

[9] Addressing Global Mortality from Ambient PM2.5 [J].

Apte, Joshua S. ;

Marshall, Julian D. ;

Cohen, Aaron J. ;

Brauer, Michael .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2015, 49 (13) :8057-8066

[10] Inflammatory effects of particulate matter air pollution [J].

Arias-Perez, Ruben D. ;

Taborda, Natalia A. ;

Gomez, Diana M. ;

Fredy Narvaez, Jhon ;

Porras, Jazmin ;

Hernandez, Juan C. .

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2020, 27 (34) :42390-42404

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