An Update on the Nitrogen Heterocycle Compositions and Properties of US FDA-Approved Pharmaceuticals (2013-2023)

被引：264

作者：

Marshall, Christopher M. ^{[1
]}

Federice, John G. ^{[1
]}

Bell, Chloe N. ^{[1
]}

Cox, Philip B. ^{[2
]}

Njardarson, Jon T. ^{[1
]}

机构：

[1] Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA

[2] AbbVie Inc, Discovery Res, N Chicago, IL 60064 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2024年 / 67卷 / 14期

基金：

美国国家科学基金会;

关键词：

SMALL-MOLECULE INHIBITOR; CLINICAL-TRIALS; DISCOVERY; POTENT; DRUG; RECEPTOR; DESIGN; AGONIST; AGENTS; ARCHITECTURES;

D O I：

10.1021/acs.jmedchem.4c01122

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This Perspective is a continuation of our analysis of U.S. FDA-approved small-molecule drugs (1938-2012) containing nitrogen heterocycles. In this study we report drug structure and property analyses of 321 unique new small-molecule drugs approved from January 2013 to December 2023 as well as information about frequency of important heteroatoms such as sulfur and fluorine and key small nitrogen substituents (CN and NO2). The most notable change is an incredible increase in drugs containing at least one nitrogen heterocycle-82%, compared to 59% from preceding decades-as well as a significant increase in the number of nitrogen heterocycles per drug. Pyridine has claimed the #1 high-frequency nitrogen heterocycle occurrence spot from piperidine (#2), with pyrimidine (#5), pyrazole (#6), and morpholine (#9) being the big top 10 climbers. Also notable is high number of fused nitrogen heterocycles, apparently driven largely by newly approved cancer drugs.

引用

页码：11622 / 11655

页数：34

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