Microbiota-gut-brain axis: Natural antidepressants molecular mechanism

被引:2
作者
Lu, Yitong [1 ]
Yu, Xiaowen [2 ,3 ]
Wang, Zhongling [3 ]
Kong, Linghui [1 ]
Jiang, Zhenyuan [3 ]
Shang, Ruirui [4 ]
Zhong, Xia [5 ]
Lv, Shimeng [1 ]
Zhang, Guangheng [1 ]
Gao, Haonan [1 ]
Yang, Ni [1 ]
机构
[1] Shandong Univ Tradit Chinese Med, Dept Clin Med Coll 1, Jinan 250014, Peoples R China
[2] Shandong Univ Tradit Chinese Med, Jinan 250355, Peoples R China
[3] Shandong Univ Tradit Chinese Med, Dept Neurol, Affiliated Hosp, Jinan 250014, Peoples R China
[4] Shandong Univ Tradit Chinese Med, Coll Rehabil Med, Jinan 250355, Peoples R China
[5] Peking Univ, Inst Child & Adolescent Hlth, Sch Publ Hlth, Beijing 100191, Peoples R China
关键词
Microbiota-gut-brain axis; Depression; Gut microbiota; Antidepressant; Molecular mechanism; Natural products; STRESS-INDUCED DEPRESSION; ANXIETY-LIKE BEHAVIOR; VALERIANA-JATAMANSI; METABOLIC PATHWAY; MEDICINAL-PLANT; CURCUMIN; MATRINE; CELLS; MOUSE; LACTOBACILLUS;
D O I
10.1016/j.phymed.2024.156012
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Background: Major depressive disorder (MDD) is a severe mental health condition characterized by persistent depression, impaired cognition, and reduced activity. Increasing evidence suggests that gut microbiota (GM) imbalance is closely linked to the emergence and advancement of MDD, highlighting the potential significance of regulating the "Microbiota-Gut-Brain" (MGB) axis to impact the development of MDD. Natural products (NPs), characterized by broad biological activities, low toxicity, and multi-target characteristics, offer unique advantages in antidepressant treatment by regulating MGB axis. Purpose: This review was aimed to explore the intricate relationship between the GM and the brain, as well as host responses, and investigated the mechanisms underlying the MGB axis in MDD development. It also explored the pharmacological mechanisms by which NPs modulate MGB axis to exert antidepressant effects and addressed current research limitations. Additionally, it proposed new strategies for future preclinical and clinical applications in the MDD domain. Methods: To study the effects and mechanism by which NPs exert antidepressant effects through mediating the MGB axis, data were collected from Web of Science, PubMed, ScienceDirect from initial establishment to March 2024. NPs were classified and summarized by their mechanisms of action. Results: NPs, such as flavonoids,alkaloids,polysaccharides,saponins, terpenoids, can treat MDD by regulating the MGB axis. Its mechanism includes balancing GM, regulating metabolites and neurotransmitters such as SCAFs, 5HT, BDNF, inhibiting neuroinflammation, improving neural plasticity, and increasing neurogenesis. Conclusions: NPs display good antidepressant effects, and have potential value for clinical application in the prevention and treatment of MDD by regulating the MGB axis. However, in-depth study of the mechanisms by which antidepressant medications affect MGB axis will also require considerable effort in clinical and preclinical research, which is essential for the development of effective antidepressant treatments.
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页数:26
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共 252 条
[1]   Involvement of the serotonergic system and neuroplasticity in the antidepressant effect of curcumin in ovariectomized rats: Comparison with oestradiol and fluoxetine [J].
Abd-Rabo, Marwa M. ;
Georgy, Gehan S. ;
Saied, Nashwa M. ;
Hassan, Wafaa A. .
PHYTOTHERAPY RESEARCH, 2019, 33 (02) :387-396
[2]   Comparison between Symptomatic and Asymptomatic Mice after Clostridioides difficile Infection Reveals Novel Inflammatory Pathways and Contributing Microbiota [J].
AbdelKhalek, Ahmed ;
Narayanan, Sanjeev K. .
MICROORGANISMS, 2022, 10 (12)
[3]   Nutritional and health beneficial properties of saffron (Crocus sativus L): a comprehensive review [J].
Abu-Izneid, Tareq ;
Rauf, Abdur ;
Khalil, Anees Ahmed ;
Olatunde, Ahmed ;
Khalid, Ahood ;
Alhumaydhi, Fahad A. ;
Aljohani, Abdullah S. M. ;
Uddin, Md Sahab ;
Heydari, Mojtaba ;
Khayrullin, Mars ;
Shariati, Mohammad Ali ;
Aremu, Adeyemi Oladapo ;
Alafnan, Ahmed ;
Rengasamy, Kannan R. R. .
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2022, 62 (10) :2683-2706
[4]   Signaling inflammation across the gut-brain axis [J].
Agirman, Gulistan ;
Yu, Kristie B. ;
Hsiao, Elaine Y. .
SCIENCE, 2021, 374 (6571) :1087-1092
[5]   Neuropharmacological interventions of quercetin and its derivatives in neurological and psychological disorders [J].
Agrawal, Kirti ;
Chakraborty, Pratik ;
Dewanjee, Saikat ;
Arfin, Saniya ;
Das, Sabya Sachi ;
Dey, Abhijit ;
Moustafa, Mahmoud ;
Mishra, Prabhu Chandra ;
Jafari, Seid Mahdi ;
Jha, Niraj Kumar ;
Jha, Saurabh Kumar ;
Kumar, Dhruv .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2023, 144
[6]   Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation [J].
Agudelo, Leandro Z. ;
Ferreira, Duarte M. S. ;
Cervenka, Igor ;
Bryzgalova, Galyna ;
Dadvar, Shamim ;
Jannig, Paulo R. ;
Pettersson-Klein, Amanda T. ;
Lakshmikanth, Tadepally ;
Sustarsic, Elahu G. ;
Porsmyr-Palmertz, Margareta ;
Correia, Jorge C. ;
Izadi, Manizheh ;
Martinez-Redondo, Vicente ;
Ueland, Per M. ;
Midttun, Oivind ;
Gerhart-Hines, Zachary ;
Brodin, Petter ;
Pereira, Teresa ;
Berggren, Per-Olof ;
Ruas, Jorge L. .
CELL METABOLISM, 2018, 27 (02) :378-+
[7]   Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease [J].
Agus, Allison ;
Planchais, Julien ;
Sokol, Harry .
CELL HOST & MICROBE, 2018, 23 (06) :716-724
[8]   The style and substance of plant flavonoid decoration; towards defining both structure and function [J].
Alseekh, Saleh ;
de Souza, Leonardo Perez ;
Benina, Maria ;
Fernie, Alisdair R. .
PHYTOCHEMISTRY, 2020, 174
[9]   Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation [J].
Arpaia, Nicholas ;
Campbell, Clarissa ;
Fan, Xiying ;
Dikiy, Stanislav ;
van der Veeken, Joris ;
deRoos, Paul ;
Liu, Hui ;
Cross, Justin R. ;
Pfeffer, Klaus ;
Coffer, Paul J. ;
Rudensky, Alexander Y. .
NATURE, 2013, 504 (7480) :451-+
[10]   Beneficial effects of butyrate on brain functions: A view of epigenetic [J].
Avila Alpino, Gabriela de Cassia ;
Pereira-Sol, Gabriela Amorim ;
de Moura e Dias, Mariana ;
de Aguiar, Aline Silva ;
Gouveia Peluzio, Maria do Carmo .
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2024, 64 (12) :3961-3970