[11C]Methionine 11 C]Methionine PET vs . [18F]Fluorodeoxyglucose 18 F]Fluorodeoxyglucose PET Whole-body Imaging to Determine the Extent of Methionine-addiction Compared to Glucose-addiction of Primary and Metastatic Cancer of the Trunk in Patients

被引：0

作者：

Sato, Motokazu ^{[1
,2
,3
]}

Sato, Toshihiko ^{[5
]}

Hozumi, Chihiro ^{[6
]}

Han, Qinghong ^{[1
]}

Mizuta, Kohei ^{[1
,2
]}

Morinaga, Sei ^{[1
,2
]}

Kang, Byung M. O. ^{[1
]}

Kobayashi, Noritoshi ^{[3
]}

Ichikawa, Yasushi ^{[3
]}

Nakajima, Atsushi ^{[4
]}

Hoffman, Robert M. ^{[1
,2
]}

机构：

[1] Anti Canc Inc, 7917 Ostrow St,Suite B, San Diego, CA 92111 USA

[2] Univ Calif San Diego, Dept Surg, San Diego, CA USA

[3] Yokohama City Univ, Dept Oncol, Sch Med, Yokohama, Japan

[4] Yokohama City Univ, Dept Gastroenterol & Hepatol, Sch Med, Yokohama, Japan

[5] Utsunomiya Cent Clin, Tochigi, Japan

[6] Anti Canc Japan Inc, Chiba, Japan

来源：

ANTICANCER RESEARCH | 2024年 / 44卷 / 09期

关键词：

Methionine; deoxyglucose; PET; comparison; methionine addiction; Hoffman effect; breast cancer; prostate cancer; bladder cancer; esophageal cancer; ORAL-RECOMBINANT METHIONINASE; POSITRON-EMISSION-TOMOGRAPHY; C-11-METHIONINE PET; MALIGNANT RAT; BREAST-CANCER; BRAIN-TUMORS; SERUM METHIONINE; PROGNOSTIC VALUE; PROSTATE-CANCER; GRADE;

D O I：

10.21873/anticanres.17216

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: Positron emission tomography (PET) is an important imaging modality, especially in oncology. [18F]fluorodeoxyglucose 18 F]fluorodeoxyglucose PET (FDG-PET) is the most used cancer PET imaging. However, since the elevated glucose use by cancers, termed the Warburg effect, is usually only moderate, FDG often does not provide a strong or well-delineated signal. Malignancies have a stronger addiction to methionine, known as the Hoffman effect, and thus [11C]methionine 11 C]methionine PET (MET- PET) has demonstrated superiority over FDG-PET in gliomas and other brain tumors. Our team is pioneering the use of MET- PET for tumors of the trunk for both better detection of cancer and to determine candidates for methionine-restriction therapy. The present study provides examples of cancers of organs in the trunk in which MET-PET outperforms FDG-PET in detecting and delineating primary and metastatic cancer. Patients and Methods: In all cases, MET-PET and FDG-PET were performed simultaneously. An evaluation of the images was conducted by a nuclear medicine physician. Results: Four cases, including prostate, bladder, esophageal, and breast cancer demonstrated the superiority of MET-PET compared to FDG-PET. Conclusion: MET-PET can out-perform FDG PET for accurate detection of primary and metastatic cancer in the trunk and can determine the extent of methionine addiction of cancer, thereby indicating whether cancer patients can benefit from methionine-restriction therapy.

引用

页码：3891 / 3898

页数：8

共 75 条

[21] Oral dosing of Recombinant Methioninase Is Associated With a 70% Drop in PSA in a Patient With Bone-metastatic Prostate Cancer and 50% Reduction in Circulating Methionine in a High-stage Ovarian Cancer Patient [J].