Gradient scaffolds for osteochondral tissue engineering and regeneration

被引：6

作者：

Xiong, Ziqi ^{[1
,2
,3
]}

Hong, Fangyuan ^{[1
,2
,3
]}

Wu, Zhonglin ^{[1
,2
,3
,4
]}

Ren, Yijia ^{[1
,2
,3
]}

Sun, Nuola ^{[1
,2
,3
]}

Heng, Boon Chin ^{[5
]}

Zhou, Jing ^{[1
,2
,3
,6
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Sports Med, Hangzhou, Peoples R China

[2] Zhejiang Univ, Liangzhu Lab, Sch Med, Hangzhou, Peoples R China

[3] Zhejiang Univ, Sch Med, Dr Li Dak Sum & Yip Yio Chin Ctr Stem Cells & Rege, Hangzhou, Peoples R China

[4] Zhejiang Univ, Affiliated First Hangzhou Peoples Hosp, Dept Hepatobiliary & Pancreat Surg, Key Lab Integrated Oncol & Intelligent Med Zhejian, Hangzhou 310006, Peoples R China

[5] Peking Univ, Sch Stomatol, Beijing, Peoples R China

[6] China Orthoped Regenerat Med Grp CORMed, Hangzhou, Peoples R China

来源：

CHEMICAL ENGINEERING JOURNAL | 2024年 / 498卷

关键词：

Osteochondral defect; Integration; Gradient scaffolds; Tissue engineering; MESENCHYMAL STEM-CELLS; ARTICULAR-CARTILAGE; MECHANICAL-PROPERTIES; TOP-STEREOLITHOGRAPHY; ZONAL ORGANIZATION; SOLUTE TRANSPORT; SUBCHONDRAL BONE; DEFECT REPAIR; SILK FIBROIN; DIFFERENTIATION;

D O I：

10.1016/j.cej.2024.154797

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

In recent years, the incidence of osteoarthritis (OA) has been increasing worldwide. This disease not only affects the articular cartilage but also impairs the subchondral bone and surrounding tissues. Therefore, there has been much research dedicated to osteochondral defect repair. In tissue engineering, integrated gradient tissueengineered osteochondral scaffold has been proposed as a promising treatment, that can simultaneously repair articular cartilage, osteochondral interface, and subchondral bone. It is possible to identify a variety of physiological gradients between the surface of the articular cartilage and the subchondral bone. Simulating these gradients in scaffold design is an effective way to regenerate osteochondral tissue. Starting from various physiological gradients, this review provides an overview of current research on gradient scaffolds for the repair of osteochondral tissue.

引用

页数：16

共 167 条

[1] A Graded, Porous Composite of Natural Biopolymers and Octacalcium Phosphate Guides Osteochondral Differentiation of Stem Cells [J].