Gastric cancer and brain metastasis: A systematic review and meta-analysis

被引：0
作者：
Fotakopoulos, George [1 ]
Christodoulidis, Grigorios [2 ]
Georgakopoulou, Vasiliki Epameinondas [3 ]
Trakas, Nikolaos [4 ]
Skapani, Pagona [4 ]
Panagiotopoulos, Konstantinos [5 ]
Spandidos, Demetrios A. [6 ]
Foroglou, Nicolas [7 ]
机构：
[1] Gen Univ Hosp Larisa, Dept Neurosurg, Mezourlo 1, Larisa 41221, Greece
[2] Gen Univ Hosp Larisa, Dept Gen Surg, Mezourlo 41221, Larisa, Greece
[3] Natl & Kapodistrian Univ Athens, Dept Pathophysiol, Athens 11527, Greece
[4] Sismanogleio Hosp, Dept Biochem, Athens 15126, Greece
[5] Gen Hosp Athens Georgios Gennimatas, Biochem Lab, Athens 11527, Greece
[6] Univ Crete, Sch Med, Lab Clin Virol, Iraklion 71003, Greece
[7] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Dept Neurosurg 1, Thessaloniki 54636, Greece
来源：
MOLECULAR AND CLINICAL ONCOLOGY | 2024年 / 21卷 / 05期
关键词：
gastric cancer; brain metastasis; surgical resection; survival outcomes; conservative or no-surgical treatment;
D O I：
10.3892/mco.2024.2775
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Gastric cancer (GC) constitutes one of the most wide-ranging cancers, with brain metastasis (BM) being a markedly uncommon and unfavorable outcome. The present meta-analysis evaluated the relationship between no-surgical treatment vs. additional surgical BM resection on the patient's quality of life and potential survival using electronic databases, including PubMed (1980-April 2024), Medline (1980-April 2024), Cochrane Library, and EMBASE (1980-April 2024). After a literature search, six articles were included in the final study pool. The number of patients with BM and conservative treatment was 289 (80.05%) compared with those that underwent an additional surgical resection 72 (19.95%). The mean age was 59.2 years, and the males were 195 (73.8%) of 264 available from five studies. The findings of the present meta-analysis revealed that the curative effect of BM tumor resection on patients with GC undergoing additional treatment with stereotactic radiosurgery, whole-brain radiotherapy or chemotherapy was favorable for their survival.
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页数：6
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