Atriplex hortensis var. 'rubra' extracts and purified amaranthin-type pigments reduce oxidative stress and inflammatory response in LPS-stimulated RAW264.7 cells

被引：4

作者：

Kumorkiewicz-Jamro, Agnieszka ^{[1
,2
,3
]}

Pachulicz, River J. ^{[4
]}

Fitter, Stephen ^{[1
,2
]}

Gorska, Renata ^{[3
]}

Duggan, Jvaughn ^{[1
,2
]}

Vandyke, Kate ^{[1
,2
]}

Pukala, Tara L. ^{[4
]}

Wybraniec, Slawomir ^{[3
]}

Zannettino, Andrew C. W. ^{[1
,2
]}

机构：

[1] Univ Adelaide, Fac Hlth & Med Sci, Sch Biomed, Myeloma Res Lab, Adelaide, SA 5000, Australia

[2] South Australian Hlth & Med Res Inst, Precis Canc Med Theme, Adelaide, SA 5000, Australia

[3] Cracow Univ Technol, Fac Chem Engn & Technol, Dept Chem Technol & Environm Anal, Warszawska 24, PL-31155 Krakow, Poland

[4] Univ Adelaide, Sch Phys Chem & Earth Sci, Discipline Chem, Adelaide, SA 5005, Australia

来源：

FOOD CHEMISTRY | 2025年 / 462卷

关键词：

Betalains; Atriplex hortensis ' rubra '; Ion mobility-mass spectrometry; Anti-inflammatory activity; Antioxidant activity; ANTIOXIDANT ACTIVITY; BETA-VULGARIS; BETALAINS; INDICAXANTHIN; CYCLOOXYGENASE; IDENTIFICATION; PROLIFERATION; BEETROOT; BIOLOGY; FRUITS;

D O I：

10.1016/j.foodchem.2024.140920

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The use of direct injection ion mobility mass spectrometry (DI-IM-MS) to detect and identify betacyanin pigments in A. hortensis ' rubra ' extracts was explored for the first time, with results compared to conventional LC-MS/MS analysis. The anti-inflammatory activities of leaf and seed extracts, alongside purified amaranthin and celosianin pigments, were investigated using a model of lipopolysaccharide (LPS)-activated murine macrophages. Extracts and purified pigments significantly inhibited the production of prostaglandin E2 2 and NO by up to 90% and 70%, respectively, and reduced the expression of Il6, , Il1b, , Nos2, , and Cox2. Leaf and seed extracts also decreased secretion of Il6 and Il1b cytokines and reduced protein levels of Nos2 and Cox2. Furthermore, extracts and purified pigments demonstrated potent dose-dependent radical scavenging activity in a cellular antioxidant activity assay (CAA) without any cytotoxic effects. Our research highlights the promising biological potential of edible, climate-resilient A. hortensis ' rubra ' as a valuable source of bioactive compounds.

引用

页数：14

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