Food protein-induced enteropathy: a revision for the clinician

被引：4

作者：

Barni, Simona ^{[1
]}

Mori, Francesca ^{[1
]}

Pecoraro, Luca ^{[2
]}

Saretta, Francesca ^{[3
]}

Giovannini, Mattia ^{[1
,4
]}

Arasi, Stefania ^{[5
]}

Liotti, Lucia ^{[6
]}

Mastrorilli, Carla ^{[7
]}

Klain, Angela ^{[8
]}

Gelsomino, Mariannita ^{[9
]}

Castagnoli, Riccardo ^{[10
]}

del Giudice, Michele Miraglia ^{[8
]}

Novembre, Elio ^{[4
]}

机构：

[1] Meyer Childrens Hosp IRCCS, Allergy Unit, Florence, Italy

[2] Univ Verona, Dept Surg Sci Dent Gynecol & Pediat, Pediat Unit, Verona, Italy

[3] Azienda Sanit Univ Friuli Cent, Gen Pediatrician, Udine, Italy

[4] Univ Florence, Dept Hlth Sci, Florence, Italy

[5] IRCCS, Bambino Gesu Childrens Hosp, Div Allergy, Translat Res Pediat Specialties Area, Rome, Italy

[6] Salesi Childrens Hosp, Dept Mother & Child Hlth, Pediat Unit, Ancona, Italy

[7] AOU Policlin Bari, Pediat Hosp Giovanni XXIII, Pediat & Emergency Dept, I-70126 Bari, Italy

[8] Univ Campania Luigi Vanvitelli, Dept Woman Child & Gen & Specialized Surg, Naples, Italy

[9] Univ Cattolica Sacro Cuore, Univ Fdn Policlin Gemelli IRCCS, Dept Life Sci & Publ Hlth, Pediat Allergy Unit, Rome, Italy

[10] Fdn IRCCS Policlin San Matteo, Pediat Clin, Pavia, Italy

来源：

FRONTIERS IN PEDIATRICS | 2024年 / 12卷

关键词：

children; enteropathy; diarrhea; food allergy; non-IgE mediated; vomiting; COWS-MILK PROTEIN; SMALL-INTESTINAL-MUCOSA; SENSITIVE ENTEROPATHY; INTRAEPITHELIAL LYMPHOCYTES; JEJUNAL MUCOSA; MALABSORPTION-SYNDROME; QUANTITATIVE-ANALYSIS; CHANGING PATTERN; DUODENAL MUCOSA; CHILDREN;

D O I：

10.3389/fped.2024.1417391

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Food protein-induced enteropathy (FPE) belongs to non-IgE gastrointestinal mediated food allergies. FPE is a syndrome characterized by diarrhea, weight loss and failure to thrive in young infants. Cow milk is the culprit food that most frequently causes FPE. The prevalence of FPE has not been fully estimated, but it is relatively rare. The diagnosis is based on the clinical manifestations and histological findings through colonoscopy. Laboratory tests are somewhat helpful in the diagnosis, although there are no disease-specific findings. Allergy testing for food specific IgE is not routinely recommended. The cornerstone of the management of FPE is the removal of culprit food from the diet. FPE is usually a transient condition that resolves in most cases by 1-2 years of life. This review addresses the latest findings on FPE, including a practical guide to assist pediatricians treating children with FPE.

引用

页数：8

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