Forsythiaside A alleviates acute lung injury via the RNF99/TRAF6/NF-κB signaling pathway

被引：0
作者：
Wang, Jing [1 ]
Xin, Linyan [2 ]
Wang, Haichao [1 ]
Xu, Lisheng [1 ]
Zhao, Fang [1 ]
Li, Wanrong [1 ]
Yang, Yang [1 ]
Wang, Weiwei [1 ]
Shan, Lingling [1 ]
机构：
[1] Suzhou Univ, Inst Pharmaceut, Sch Biol & Food Engn, Pharmacol Res Ctr, Suzhou, Anhui, Peoples R China
[2] Yancheng First Peoples Hosp, Pharm Dept, Yancheng 224006, Peoples R China
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2024年 / 140卷
基金：
美国国家科学基金会;
关键词：
RNF99; ALI; TRAF6; NF-kappa B; FA; SEPTIC SHOCK; DOWN-REGULATION; SEPSIS; EPIDEMIOLOGY;
D O I：
10.1016/j.intimp.2024.112814
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The aim of this study was to investigated the effects of forsythiaside A (FA) on acute lung injury (ALI). The lung tissue pathological was detected by hematoxylin-eosin staining (HE) staining. Wet weight/dry weight (w/d) of the lung in mice was measured. Cytokine such as interleukin 1(3 (IL-1(3), IL-6 and tumor necrosis factor-alpha (TNF-alpha) were also detected. Compared with the vector group, the protein expression levels of TRAF6 and TAK1 the RNF99 group were significantly reduced. Ubiquitinated TRAF6 protein was increased after knockdown of RNF99. Finally, it was found that FA significantly ameliorated ALI via regulation of RNF99/TRAF6/NF-kappa B signal pathway. In conclusion, RNF99 was an important biomarker in ALI and FA alleviated ALI via RNF99/ TRAF6/NF kappa B signal pathway.
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