Forsythiaside A alleviates acute lung injury via the RNF99/TRAF6/NF-κB signaling pathway

被引：0
作者：
Wang, Jing [1 ]
Xin, Linyan [2 ]
Wang, Haichao [1 ]
Xu, Lisheng [1 ]
Zhao, Fang [1 ]
Li, Wanrong [1 ]
Yang, Yang [1 ]
Wang, Weiwei [1 ]
Shan, Lingling [1 ]
机构：
[1] Suzhou Univ, Inst Pharmaceut, Sch Biol & Food Engn, Pharmacol Res Ctr, Suzhou, Anhui, Peoples R China
[2] Yancheng First Peoples Hosp, Pharm Dept, Yancheng 224006, Peoples R China
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2024年 / 140卷
基金：
美国国家科学基金会;
关键词：
RNF99; ALI; TRAF6; NF-kappa B; FA; SEPTIC SHOCK; DOWN-REGULATION; SEPSIS; EPIDEMIOLOGY;
D O I：
10.1016/j.intimp.2024.112814
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The aim of this study was to investigated the effects of forsythiaside A (FA) on acute lung injury (ALI). The lung tissue pathological was detected by hematoxylin-eosin staining (HE) staining. Wet weight/dry weight (w/d) of the lung in mice was measured. Cytokine such as interleukin 1(3 (IL-1(3), IL-6 and tumor necrosis factor-alpha (TNF-alpha) were also detected. Compared with the vector group, the protein expression levels of TRAF6 and TAK1 the RNF99 group were significantly reduced. Ubiquitinated TRAF6 protein was increased after knockdown of RNF99. Finally, it was found that FA significantly ameliorated ALI via regulation of RNF99/TRAF6/NF-kappa B signal pathway. In conclusion, RNF99 was an important biomarker in ALI and FA alleviated ALI via RNF99/ TRAF6/NF kappa B signal pathway.
引用
收藏
页数：7
相关论文
共 26 条
  • [1] Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells
    Baker, J. R.
    Vuppusetty, C.
    Colley, T.
    Papaioannou, Andriana I.
    Fenwick, P.
    Donnelly, Louise
    Ito, K.
    Barnes, P. J.
    [J]. SCIENTIFIC REPORTS, 2016, 6
  • [2] MiR-34a/c-Dependent PDGFR-α/β Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer
    Garofalo, Michela
    Jeon, Young-Jun
    Nuovo, Gerard J.
    Middleton, Justin
    Secchiero, Paola
    Joshi, Pooja
    Alder, Hansjuerg
    Nazaryan, Natalya
    Di Leva, Gianpiero
    Romano, Giulia
    Crawford, Melissa
    Nana-Sinkam, Patrick
    Croce, Carlo M.
    [J]. PLOS ONE, 2013, 8 (06):
  • [3] PIASy inhibits LRH-1-dependent CYP11A1 expression by competing for SRC-1 binding
    Hsieh, Hsiang-Tsan
    Wang, Chih-Hung
    Wu, Mei-Ling
    Yang, Feng-Ming
    Tai, Yu-Chen
    Hu, Meng-Chun
    [J]. BIOCHEMICAL JOURNAL, 2009, 419 : 201 - 209
  • [4] Intranasal versus intratracheal exposure to lipopolysaccharides in a murine model of acute respiratory distress syndrome
    Khadangi, Fatemeh
    Forgues, Anne-Sophie
    Tremblay-Pitre, Sophie
    Dufour-Mailhot, Alexis
    Henry, Cyndi
    Boucher, Magali
    Beaulieu, Marie-Josee
    Morissette, Mathieu
    Fereydoonzad, Liah
    Brunet, David
    Robichaud, Annette
    Bosse, Ynuk
    [J]. SCIENTIFIC REPORTS, 2021, 11 (01)
  • [5] PEP-1-p18 prevents neuronal cell death by inhibiting oxidative stress and Bax expression
    Kim, Duk-Soo
    Sohn, Eun Jeong
    Kim, Dae Won
    Kim, Young Nam
    Eom, Seon Ae
    Yoon, Ga Hyeon
    Cho, Sung-Woo
    Lee, Sang-Hyun
    Hwang, Hyun Sook
    Cho, Yoon Shin
    Park, Jinseu
    Eum, Won Sik
    Choi, Soo Young
    [J]. BMB REPORTS, 2012, 45 (09) : 532 - 537
  • [6] PEP-1-PON1 Protein Regulates Inflammatory Response in Raw 264.7 Macrophages and Ameliorates Inflammation in a TPA-Induced Animal Model
    Kim, Mi Jin
    Jeong, Hoon Jae
    Kim, Dae Won
    Sohn, Eun Jeong
    Jo, Hyo Sang
    Kim, Duk-Soo
    Kim, Hyun Ah
    Park, Eun Young
    Park, Jong Hoon
    Son, Ora
    Han, Kyu Hyung
    Park, Jinseu
    Eum, Won Sik
    Choi, Soo Young
    [J]. PLOS ONE, 2014, 9 (01):
  • [7] A peptide derived from chaperonin 60.1, IRL201104, inhibits LPS-induced acute lung inflammation
    Man, Francis
    Nadkarni, Suchita
    Kanabar, Varsha
    E-Lacerda, Rodrigo R.
    Ferreira, Sueli Gomes
    Canova, Donata Federici
    Perretti, Mauro
    Page, Clive P.
    Riffo-Vasquez, Yanira
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2021, 321 (05) : L803 - L813
  • [8] The epidemiology of sepsis in the United States from 1979 through 2000
    Martin, GS
    Mannino, DM
    Eaton, S
    Moss, M
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (16) : 1546 - 1554
  • [9] A peptide carrier for the delivery of biologically active proteins into mammalian cells
    Morris, MC
    Depollier, J
    Mery, J
    Heitz, F
    Divita, G
    [J]. NATURE BIOTECHNOLOGY, 2001, 19 (12) : 1173 - 1176
  • [10] Vital Signs: Epidemiology of Sepsis: Prevalence of Health Care Factors and Opportunities for Prevention
    Novosad, Shannon A.
    Sapiano, Mathew R. P.
    Grigg, Cheri
    Lake, Jason
    Robyn, Misha
    Dumyati, Ghinwa
    Felsen, Christina
    Blog, Debra
    Dufort, Elizabeth
    Zansky, Shelley
    Wiedeman, Kathryn
    Avery, Lacey
    Dantes, Raymund B.
    Jernigan, John A.
    Magill, Shelley S.
    Fiore, Anthony
    Epstein, Lauren
    [J]. MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2016, 65 (33): : 864 - 869
123