Unachieved antiviral strategies with acyclic nucleoside phosphonates: Dedicated to the memory of dr. Salvatore "Sam" Joseph Enna

被引：5
作者：
De Clercq, Erik [1 ]
Li, Guangdi [2 ]
Zhang, Yun [3 ]
Huang, Jie [2 ]
Tan, Li [4 ]
机构：
[1] Katholieke Univ Leuven, Rega Inst Med Res, Dept Microbiol Immunol & Transplantat, B-3000 Leuven, Belgium
[2] Cent South Univ, Xiangya Sch Publ Hlth, Changsha 410078, Peoples R China
[3] Huaihua City Maternal & Child Hlth Care Hosp, Huaihua 418000, Peoples R China
[4] Cent South Univ, Xiangya Hosp 2, Hunan Clin Mol Diag Ctr, Clin Med Res Ctr Mol Diag Infect Dis Hunan Prov,Mo, Changsha 410011, Peoples R China
来源：
BIOCHEMICAL PHARMACOLOGY | 2024年 / 228卷
关键词：
Acyclic nucleoside phosphonates; Drug discovery; Tenofovir; Cidofovir; RECURRENT RESPIRATORY PAPILLOMATOSIS; POLYOMAVIRUS BK REPLICATION; INTRALESIONAL CIDOFOVIR; LARYNGEAL PAPILLOMATOSIS; IN-VITRO; VIRUS-REPLICATION; NUCLEOTIDE ANALOG; AMIDATE PRODRUGS; DNA-POLYMERASE; DOUBLE-BLIND;
D O I：
10.1016/j.bcp.2024.116448
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Many acyclic nucleoside phosphonates such as cidofovir, adefovir dipivoxil, tenofovir disoproxil fumarate, and tenofovir alafenamide have been marketed for the treatment or prophylaxis of infectious diseases. Here, this review highlights potent acyclic nucleoside phosphonates for their potential in the treatment of retrovirus (e.g., human immunodeficiency virus) and DNA virus (e.g., adeno-, papilloma-, herpes- and poxvirus) infections. If properly assessed and/or optimized, some potent acyclic nucleoside phosphonates can be possibly applied in the control of current and emerging infectious diseases.
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页数：10
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