Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of an Optimized Dual GLP-1/GIP Receptor Agonist (BGM0504) in Healthy Subjects-A Phase Ia, Randomized, Double-Blind, Placebo-Controlled, Ascending Dose Study

被引:0
|
作者
Yuan, Jiandong
Huang, Yangqing
Ding, Haifeng
Jiang, Xiaohui
机构
关键词
D O I
10.2337/db24-849-P
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
849-P
引用
收藏
页数:2
相关论文
共 50 条
  • [31] A Randomized, Placebo-Controlled, Double-Blind Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Repeated Doses of Mirogabalin in Healthy Asian Volunteers
    Jansen, Mendel
    Warrington, Steven
    Dishy, Victor
    Ohwada, Shoichi
    Johnson, Lisa
    Brown, Karen
    Ishizuka, Hitoshi
    CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2018, 7 (06): : 661 - 669
  • [32] Correction to: A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects
    Lesley Taylor
    Barry Gidal
    Graham Blakey
    Bola Tayo
    Gilmour Morrison
    CNS Drugs, 2019, 33 : 397 - 397
  • [33] Safety, Tolerability and Pharmacokinetics of Dalcetrapib Following Single and Multiple Ascending Doses in Healthy SubjectsA Randomized, Double-Blind, Placebo-Controlled, Phase I Study
    Michael Derks
    Judith Anzures-Cabrera
    Lynn Turnbull
    Mary Phelan
    Clinical Drug Investigation, 2011, 31 : 325 - 335
  • [34] Safety, pharmacokinetics (PK), and pharmacodynamics (PD) of a dual GLP-1/GIP receptor agonist HRS9531 in T2DM patients
    Zhao, L.
    Wen, Q.
    Zhang, Y.
    Yu, G.
    Pan, T.
    Wang, Y.
    Li, F.
    Jin, P.
    Jiang, H.
    Zeng, M.
    Li, X.
    Li, X.
    DIABETES RESEARCH AND CLINICAL PRACTICE, 2024, 209
  • [35] A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Evaluate the Pharmacokinetics, Immunogenicity, Safety, and Tolerability After Subcutaneous Administration of Tozorakimab in Healthy Chinese Participants
    Li, Yunfei
    Zhang, Hua
    Pandya, Hitesh
    Miao, Liyan
    Reid, Fred
    Jimenez, Eulalia
    Sadiq, Muhammad Waqas
    Moate, Rachel
    Lei, Alejhandra
    Zhou, Xiao-Hong
    Kell, Chris
    Ding, Junjie
    Zhang, Guanlin
    Zhao, Lina
    Ge, Xiaoyun
    CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2024, 13 (06): : 665 - 671
  • [36] Safety, Tolerability, and Pharmacokinetics of Kukoamine B in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Phase I Study
    Zhao, Qian
    Liu, Hongzhong
    Wang, Zhenlei
    Wang, Teng
    Cui, Cheng
    Wang, Huanhuan
    Li, Lili
    Zhong, Wen
    Jiang, Ji
    Dong, Kai
    Chen, Shuai
    Jin, Chunyan
    Hu, Pei
    ADVANCES IN THERAPY, 2023, 40 (07) : 3186 - 3198
  • [37] Safety, Tolerability, and Pharmacokinetics of Kukoamine B in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Phase I Study
    Qian Zhao
    Hongzhong Liu
    Zhenlei Wang
    Teng Wang
    Cheng Cui
    Huanhuan Wang
    Lili Li
    Wen Zhong
    Ji Jiang
    Kai Dong
    Shuai Chen
    Chunyan Jin
    Pei Hu
    Advances in Therapy, 2023, 40 : 3186 - 3198
  • [38] A Double-Blinded, Placebo Controlled, Single Ascending Dose Study for Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics after Subcutaneous Administration of Novel Long-Acting GLP-1/GIP/Glucagon Triple Agonist (HM15211) in Healthy Obese Subjects
    Choi, Jae Duk
    Baek, Seungjae
    Kim, Youngmin
    Eun, Kahee
    Kwon, Se Chang
    Morrow, Linda
    Hompesch, Marcus
    Kang, Jahoon
    DIABETES, 2019, 68
  • [39] A Phase 1, Single-Center, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Intravenous and Subcutaneous Garadacimab (CSL312) in Healthy Subjects
    McKenzie, Andrew
    Roberts, Anthony
    Malandkar, Sourabh
    Feuersenger, Henrike
    Panousis, Con
    Pawaskar, Dipti
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2021, 147 (02) : AB137 - AB137
  • [40] Safety, tolerability, and pharmacokinetics of HRS9432(A) injection in healthy Chinese subjects: a phase-I randomized, double-blind, dose escalation, placebo-controlled study
    Yan, Xin
    Huang, Yuanyuan
    Xie, Jinlian
    Wu, Qian
    Yang, Shuang
    Yang, Xiaoyan
    Chen, Honghui
    Huang, Jie
    Yang, Guoping
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2024, 68 (07) : e0052424