The Role of Alpha-Synuclein in Neurodevelopmental Diseases

被引：0
作者：
Bordbar, Sanaz [1 ,2 ]
Alijanzadeh, Dorsa [2 ,3 ,4 ]
Samieefar, Noosha [2 ,3 ,4 ]
Khazeei Tabari, Mohammad Amin [2 ,5 ,6 ]
Pourbakhtyaran, Elham [2 ,3 ,7 ]
Rezaei, Nima [2 ,8 ,9 ]
机构：
[1] Univ Tehran Med Sci, Students Sci Res Ctr, Tehran 1417755331, Iran
[2] Universal Sci Educ & Res Network USERN, Network Interdisciplinar Neonates & Infants NINI, Tehran, Iran
[3] Shahid Beheshti Univ Med Sci, Sch Med, Tehran, Iran
[4] Shahid Beheshti Univ Med Sci, USERN Off, Tehran, Iran
[5] Mazandaran Univ Med Sci, Student Res Comm, Sari, Iran
[6] Mazandaran Univ Med Sci, USERN Off, Sari, Iran
[7] Univ Tehran Med Sci, Pediat Ctr Excellence, Childrens Med Ctr, Dept Pediat Neurol, Tehran, Iran
[8] Univ Tehran Med Sci, Childrens Med Ctr Hosp, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Dr Qarib St,Keshavarz Blvd, Tehran 14194, Iran
[9] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran
来源：
MOLECULAR NEUROBIOLOGY | 2025年 / 62卷 / 01期
基金：
英国科研创新办公室;
关键词：
Neurodevelopmental disorders; Autism spectrum disorder; Attention deficit hyperactivity disorder; Alpha-synuclein; AUTISM SPECTRUM DISORDER; PROTEIN-LEVELS; TAU-PROTEIN; A-BETA; EXPRESSION; CHILDREN; SERUM; NEUROTRANSMISSION; HYPERACTIVITY; DEFICIT;
D O I：
10.1007/s12035-024-04305-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Neurodevelopmental disorders are a group of diseases with cognitive, motor, and emotional development deficits. Alpha-synuclein (alpha-syn) is a synaptic protein involved in transmission and neurodevelopment. This protein was previously shown to be associated with several disorders, including Parkinson's disease. Furthermore, a close link between neurodevelopmental disorders and Parkinson's has also been found. Changes in synaptic function have been noticed in neurodevelopmental disorders, including autism spectrum disorder. Impaired neurogenesis and related cognitive problems have been associated with altered expression of alpha-syn. Various studies reported alpha-syn in different body fluids and tissues such as blood and serum. Alpha-synuclein can help in better understanding the pathogenesis of neurodevelopmental diseases and facilitating their early diagnosis. This review aims to go over the recent advances in the role of alpha-syn in the pathophysiology of neurodevelopmental disorders, including autism spectrum disorder, attention deficit hyperactivity disorder, and motor and social impairment, and its value as a diagnostic biomarker.
引用
收藏
页码：962 / 972
页数：11
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