Transcutaneous auricular vagus nerve stimulation enhanced emotional inhibitory control via increasing intrinsic prefrontal couplings

被引:4
作者
Zhu, Siyu [1 ,2 ,3 ]
Liu, Qi [1 ]
Zhang, Xiaolu [9 ]
Zhou, Menghan [1 ]
Zhou, Xinqi [4 ]
Ding, Fangyuan [5 ]
Zhang, Rong [6 ,7 ]
Becker, Benjamin [1 ,8 ]
Kendrick, Keith M. [1 ]
Zhao, Weihua [1 ]
机构
[1] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Ctr Psychosomat Med, Sichuan Prov Ctr Mental Hlth, Chengdu 611731, Peoples R China
[2] Chengdu Sport Univ, Sch Sport Training, Lab Sport Psychol, Chengdu 610041, Peoples R China
[3] Sichuan Normal Univ, Sichuan Key Lab Psychol & Behav Discipline Inspect, Chengdu 610066, Peoples R China
[4] Sichuan Normal Univ, Inst Brain & Psychol Sci, Chengdu 610066, Peoples R China
[5] Guizhou Minzu Univ, Coll Natl Culture & Cognit Sci, Guiyang 550025, Peoples R China
[6] Peking Univ, Natl Comm Hlth & Family Planning China, Sch Basic Med Sci, Neurosci Res Inst,Key Lab Neurosci,Minist Educ Chi, Beijing 100191, Peoples R China
[7] Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing 100191, Peoples R China
[8] Univ Hong Kong, Dept Psychol, State Key Lab Brain & Cognit Sci, Hong Kong 999077, Peoples R China
[9] Fudan Univ, Anhui Childrens Hosp, Pediat Hosp, Hefei 230051, Peoples R China
基金
中国国家自然科学基金;
关键词
Inhibitory control; Transcutaneous auricular vagus nerve stimulation; Computational modeling; Dynamic functional connectivity; Mediation model; GO/NO-GO TASK; RESPONSE-INHIBITION; ELECTRICAL-STIMULATION; IMPULSIVITY; ATOMOXETINE; ACTIVATION; CORTEX; ADHD;
D O I
10.1016/j.ijchp.2024.100462
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Background: Inhibitory control represents a core executive function that critically facilitates adaptive behavior and survival in an ever-changing environment. Non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) has been hypothesized to improve behavioral inhibition performance, however the neurocomputational mechanism of taVNS-induced neuroenhancement remains elusive. Method: In the current study, we investigated the efficacy of taVNS in a sham-controlled between-subject functional near infrared spectroscopy (fNIRS) experiment with an emotional face Go/No-Go paradigm in ninety healthy young adults. Results: After a data quality check, eighty-two subjects were included in the final data analysis. Behaviorally, the taVNS improved No-Go response accuracy, together with computational modeling using Hierarchical Bayesian estimation of the Drift Diffusion Model (HDDM) indicating that it specifically reduced the information accumulation rate for Go responses, and this was negatively associated with increased accuracy of No-Go responses. On the neural level, taVNS enhanced engagement of the bilateral inferior frontal gyrus (IFG) during inhibition of angry expression faces and modulated functional couplings (FCs) within the prefrontal inhibitory control network. Mediation models revealed that taVNS-induced facilitation of inhibitory control was critically mediated by a decreased information accumulation for Go responses and concomitantly enhanced neurofunctional coupling between the inferior and orbital frontal cortex. Discussion: Our findings demonstrate a potential for taVNS to improve emotional inhibitory control via reducing pre-potent responses and enhancing FCs within prefrontal inhibitory control networks, suggesting a promising therapeutic role in treating specific disorders characterized by inhibitory control deficits.
引用
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页数:10
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