Reduction of RNA-Editing Enzyme ADAR1 in Human Islets Triggers an Interferon Response and Impairs Beta-Cell Function

被引：0
|
作者：
Dai, Chunhua
Singh, Ajay K.
Brantley, Rebekah
Bradley, Amber
Jenkins, Regina
Saunders, Diane C.
Brissova, Marcela
Levanon, Erez
Klochendler, Agnes
Dor, Yuval
Powers, Alvin C.
机构：
来源：
DIABETES | 2024年 / 73卷
关键词：
D O I：
10.2337/db24-349-OR
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
349-OR
引用
收藏
页数：2
相关论文
共 50 条
  • [41] RNA editing enzyme ADAR1 drives leukemia stem cell differentiation and self-renewal in chronic myeloid leukemia
    Jiang, Qingfei
    Leu, Heather
    Shih, Alice
    Goff, Daniel
    Court-Recart, Angela
    Ma, Wenxue
    Smith, Kristen
    Sadarangani, Anil
    Geron, Ifat
    Barrett, Christian
    Frazer, Kelly A.
    Crews, Leslie A.
    Jamieson, Catriona H. M.
    CANCER RESEARCH, 2012, 72
  • [42] Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction (vol 41, pg 891, 2020)
    Marshall, Paul R.
    Zhao, Qiongyi
    Li, Xiang
    Wei, Wei
    Periyakaruppiah, Ambika
    Zajaczkowski, Esmi L.
    Leighton, Laura J.
    Madugalle, Sachithrani U.
    Basic, Dean
    Wang, Ziqi
    Yin, Jiayu
    Liau, Wei-Siang
    Gupte, Ankita
    Walkley, Carl R.
    Bredy, Timothy W.
    NATURE NEUROSCIENCE, 2020, 23 (08) : 1034 - 1034
  • [43] The solution structure of the Zα domain of the human RNA editing enzyme ADAR1 reveals a prepositioned binding surface for Z-DNA
    Schade, M
    Turner, CJ
    Kühne, R
    Schmieder, P
    Lowenhaupt, K
    Herbert, A
    Rich, A
    Oschkinat, H
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (22) : 12465 - 12470
  • [44] Suppression of A-to-I RNA-editing enzyme ADAR1 sensitizes hepatocellular carcinoma cells to oxidative stress through regulating Keap1/Nrf2 pathway
    Wang, Houhong
    Wei, Xiaoyu
    Liu, Lu
    Zhang, Junfeng
    Li, Heng
    EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2024, 13 (01)
  • [45] The Zab domain of the human RNA editing enzyme ADAR1 recognizes Z-DNA when surrounded by B-DNA
    Kim, YG
    Lowenhaupt, K
    Maas, S
    Herbert, A
    Schwartz, T
    Rich, A
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (35) : 26828 - 26833
  • [46] Suppression of A-to-I RNA-editing enzyme ADAR1 sensitizes hepatocellular carcinoma cells to oxidative stress through regulating Keap1/Nrf2 pathway
    Houhong Wang
    Xiaoyu Wei
    Lu Liu
    Junfeng Zhang
    Heng Li
    Experimental Hematology & Oncology, 13
  • [47] A 6 bp Z-DNA hairpin binds two Zα domains from the human RNA editing enzyme ADAR1
    Schade, M
    Behlke, J
    Lowenhaupt, K
    Herbert, A
    Rich, A
    Oschkinat, H
    FEBS LETTERS, 1999, 458 (01): : 27 - 31
  • [48] Differential regulation of expression of RNA-editing enzymes, ADAR1 and ADAR2, by 5-aza-2′-deoxycytidine and trichostatin A in human neuronal SH-SY5Y cells
    Uchida, Hitoshi
    Ito, Seiji
    NEUROREPORT, 2015, 26 (18) : 1089 - 1094
  • [49] PROLONGED EXPOSURE OF HUMAN PANCREATIC-ISLETS TO HIGH GLUCOSE-CONCENTRATIONS INVITRO IMPAIRS THE BETA-CELL FUNCTION
    EIZIRIK, DL
    KORBUTT, GS
    HELLERSTROM, C
    JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (04): : 1263 - 1268
  • [50] Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis (vol 35, pg 4407, 2016)
    Anadon, C.
    Guil, S.
    Simo-Riudalbas, L.
    Moutinho, C.
    Setien, F.
    Martinez-Cardus, A.
    Moran, S.
    Villanueva, A.
    Calaf, M.
    Vidal, A.
    Lazo, P. A.
    Zondervan, I.
    Savola, S.
    Kohno, T.
    Yokota, J.
    Ribas de Pouplana, L.
    Esteller, M.
    ONCOGENE, 2016, 35 (33) : 4407 - 4413
12345