Reduction of RNA-Editing Enzyme ADAR1 in Human Islets Triggers an Interferon Response and Impairs Beta-Cell Function

被引：0
|
作者：
Dai, Chunhua
Singh, Ajay K.
Brantley, Rebekah
Bradley, Amber
Jenkins, Regina
Saunders, Diane C.
Brissova, Marcela
Levanon, Erez
Klochendler, Agnes
Dor, Yuval
Powers, Alvin C.
机构：
来源：
DIABETES | 2024年 / 73卷
关键词：
D O I：
10.2337/db24-349-OR
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
349-OR
引用
收藏
页数：2
相关论文
共 50 条
  • [21] The human but not the Xenopus RNA-editing enzyme ADAR1 has an atypical nuclear localization signal and displays the characteristics of a shuttling protein
    Eckmann, CR
    Neunteufl, A
    Pfaffstetter, L
    Jantsch, MF
    MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (07) : 1911 - 1924
  • [22] Expression and function of the interferon-inducible double-stranded RNA A-to-I editing enzyme ADAR1
    Samuel, Charles E.
    George, Cyril X.
    Li, Zhiqun
    WAng, Ying
    Toth, Annie M.
    Zhang, Ping
    JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2007, 27 (08): : 698 - 699
  • [23] Stress Response Function of ADAR1 RNA Editing Enzyme Regulated by MAP Kinases and Its Relevance to Cancer
    Nishikura, Kazuko
    CANCER SCIENCE, 2018, 109 : 397 - 397
  • [24] Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction
    Marshall, Paul R.
    Zhao, Qiongyi
    Li, Xiang
    Wei, Wei
    Periyakaruppiah, Ambika
    Zajaczkowski, Esmi L.
    Leighton, Laura J.
    Madugalle, Sachithrani U.
    Basic, Dean
    Wang, Ziqi
    Yin, Jiayu
    Liau, Wei-Siang
    Gupte, Ankita
    Walkley, Carl R.
    Bredy, Timothy W.
    NATURE NEUROSCIENCE, 2020, 23 (06) : 718 - +
  • [25] Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction
    Paul R. Marshall
    Qiongyi Zhao
    Xiang Li
    Wei Wei
    Ambika Periyakaruppiah
    Esmi L. Zajaczkowski
    Laura J. Leighton
    Sachithrani U. Madugalle
    Dean Basic
    Ziqi Wang
    Jiayu Yin
    Wei-Siang Liau
    Ankita Gupte
    Carl R. Walkley
    Timothy W. Bredy
    Nature Neuroscience, 2020, 23 : 718 - 729
  • [26] The RNA-editing enzyme ADAR1 is localized to the nascent ribonucleoprotein matrix on Xenopus lampbrush chromosomes but specifically associates with an atypical loop
    Eckmann, CR
    Jantsch, MF
    JOURNAL OF CELL BIOLOGY, 1999, 144 (04): : 603 - 615
  • [27] Distinct in vivo roles for double-stranded RNA-binding domains of the Xenopus RNA-editing enzyme ADAR1 in chromosomal targeting
    Doyle, M
    Jantsch, ME
    JOURNAL OF CELL BIOLOGY, 2003, 161 (02): : 309 - 319
  • [28] The snoRNA-like lncRNA LNC-SNO49AB drives leukemia by activating the RNA-editing enzyme ADAR1
    Huang, Wei
    Sun, Yu-Meng
    Pan, Qi
    Fang, Ke
    Chen, Xiao-Tong
    Zeng, Zhan-Cheng
    Chen, Tian-Qi
    Zhu, Shun-Xin
    Huang, Li-Bin
    Luo, Xue-Qun
    Wang, Wen-Tao
    Chen, Yue-Qin
    CELL DISCOVERY, 2022, 8 (01)
  • [29] The crystal structure of the Zβ domain of the RNA-editing enzyme ADAR1 reveals distinct conserved surfaces among Z-domains
    Athanasiadis, A
    Placido, D
    Maas, S
    Brown, BA
    Lowenhaupt, K
    Rich, A
    JOURNAL OF MOLECULAR BIOLOGY, 2005, 351 (03) : 496 - 507
  • [30] Conformational exchange of the Zα domain of human RNA editing enzyme ADAR1 studied by NMR spectroscopy
    Go, Youyeon
    Ahn, Hye-Bin
    Kim, Byeong-Seon
    Lee, Ae-Ree
    Oh, Kwang-Im
    Lee, Joon-Hwa
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021, 580 : 63 - 66
12345