Prevalence of Gastric Precursor Lesions in Countries With Differential Gastric Cancer Burden: A Systematic Review and Meta-analysis

被引：14

作者：

Mulder, Duco T. ^{[1
]}

Hahn, Anne I. ^{[2
]}

Huang, Robert J. ^{[3
]}

Zhou, Margaret J. ^{[3
]}

Blake, Benjamin ^{[4
]}

Omofuma, Omonefe ^{[5
]}

Murphy, John D. ^{[5
]}

Gutierrez-Torres, Daniela S. ^{[5
]}

Zauber, Ann G. ^{[2
]}

O'Mahony, James F. ^{[1
,6
]}

Camargo, M. Constanza ^{[5
]}

Ladabaum, Uri ^{[3
]}

Yeh, Jennifer M. ^{[7
]}

Hur, Chin ^{[8
,9
]}

Lansdorp-Vogelaar, Iris ^{[1
]}

Meester, Reinier ^{[1
,10
]}

Laszkowska, Monika ^{[11
]}

机构：

[1] Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands

[2] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY USA

[3] Stanford Univ, Sch Med, Div Gastroenterol & Hepatol, Stanford, CA USA

[4] Cornell Univ, Weill Cornell Med Coll, New York, NY USA

[5] NCI, Div Canc Epidemiol & Genet, Rockville, MD USA

[6] Univ Coll Dublin, Sch Econ, Dublin, Ireland

[7] Harvard Med Sch, Childrens Hosp Boston, Dept Pediat, Boston, MA USA

[8] Columbia Univ, Irving Med Ctr, Dept Med, Div Gen Med, New York, NY USA

[9] Columbia Univ, Irving Med Ctr, Herbert Irving Comprehens Canc Ctr, New York, NY USA

[10] Freenome Holdings Inc, Hlth Econ & Outcomes Res, San Francisco, CA USA

[11] Mem Sloan Kettering Canc Ctr, Dept Subspecialty Med, Gastroenterol Hepatol & Nutr Serv, New York, NY USA

来源：

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY | 2024年 / 22卷 / 08期

基金：

美国国家卫生研究院;

关键词：

full-text review; Intestinal Metaplasia; Dysplasia; Gastric Cancer; Gastrointestinal Endoscopy; Helicobacter Pylori; HELICOBACTER-PYLORI; SCREENING-PROGRAM; EPIDEMIOLOGY; TRENDS; RISK; RARE;

D O I：

10.1016/j.cgh.2024.02.023

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background & aims: The prevalence of precursor lesions for gastric cancer (GC) and the differential burden between countries of varying GC risk is not well-understood. We conducted a systematic review and meta-analysis to estimate the global prevalence of precursor lesions. Methods: We estimated the prevalence of atrophic gastritis (AG), gastric intestinal metaplasia (IM), and dysplasia in regions with low, medium, and high GC incidence. Because IM is an advanced manifestation of AG, we assessed the prevalence of less advanced precursors, regardless of the presence of more advanced lesions. Prevalence was sub-stratified by Helicobacter pylori infection, symptomatology, and period (<2000, 2000-2010, and >2010). Results: Among the 582 articles that underwent full-text review, 166 studies met inclusion criteria. The global prevalence estimates of AG, IM, and dysplasia were 25.4%, 16.2%, and 2.0%, respectively, on the basis of 126 studies that reported the prevalence of less advanced precursors, regardless of the presence of more advanced lesions. The prevalence of all precursor lesions was higher in high and medium compared with low GC incidence countries (P < .01). Prevalence of AG and IM was significantly higher among H pylori-infected individuals (P < .01) but not statistically different between symptomatic and asymptomatic individuals (P > .17). All precursors demonstrated a secular decrease in prevalence over time. Conclusions: Gastric precursor lesions have differences in prevalence in regions with differential GC incidence and are associated with H pylori infection. Because of the substantial prevalence of precursor lesions in both symptomatic and asymptomatic individuals, symptomatic evaluation may not be sufficient to identify individuals at risk. These estimates provide important insights for tailoring GC prevention strategies.

引用

页码：1605 / 1617

页数：13

共 31 条

[1] AGA Technical Review on Gastric Intestinal Metaplasia-Epidemiology and Risk Factors [J].