Autophagy in aging-related diseases and cancer: Principles, regulatory mechanisms and therapeutic potential

被引：15

作者：

Wu, Na ^{[1
]}

Zheng, Wenhui ^{[2
]}

Zhou, Yundong ^{[3
]}

Tian, Yu ^{[4
,5
]}

Tang, Min ^{[6
]}

Feng, Xiaoqiang ^{[7
]}

Ashrafizadeh, Milad ^{[8
,9
]}

Wang, Yuzhuo ^{[10
]}

Niu, Xiaojia ^{[10
]}

Tambuwala, Murtaza ^{[11
]}

Wang, Lingzhi ^{[12
]}

Tergaonkar, Vinay ^{[13
]}

Sethi, Gautam ^{[12
,14
]}

Klionsky, Daniel ^{[15
,16
]}

Huang, Li ^{[7
]}

Gu, Ming ^{[17
]}

机构：

[1] China Med Univ, Dept Infect Dis, Hosp 1, Shenyang 110001, Liaoning, Peoples R China

[2] China Med Univ, Dept Anesthesiol, Shengjing Hosp, Shenyang 110001, Liaoning, Peoples R China

[3] Ningbo Univ, Ningbo Med Ctr Lihuili Hosp, Dept Thorac Surg, Ningbo 315040, Zhejiang, Peoples R China

[4] Benedictine Univ, Sch Publ Hlth, 5700 Coll Rd, Lisle, IL 60532 USA

[5] Guangdong Med Univ, Huizhou Cent Peoples Hosp, Res Ctr, Huizhou, Guangdong, Peoples R China

[6] Chongqing Univ, Chongqing Gen Hosp, Dept Oncol, Chongqing 401120, Peoples R China

[7] Gaozhou Peoples Hosp, Ctr Stem Cell & Regenerat Med, 89 Xiguan Rd, Gaozhou 525200, Guangdong, Peoples R China

[8] Shandong First Med Univ, Shandong Canc Hosp & Inst, Shandong Acad Med Sci, Dept Radiat Oncol,Shandong Prov Key Lab Radiat On, Jinan 250000, Shandong, Peoples R China

[9] Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Shanghai 200032, Peoples R China

[10] Univ British Columbia, Vancouver Prostate Ctr, Dept Urol Sci, Vancouver, BC V6H3Z6, Canada

[11] Univ Lincoln, Lincoln Med Sch, Brayford Pool Campus, Lincoln LN6 7TS, England

[12] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, 16 Med Dr, Singapore 117600, Singapore

[13] ASTAR, Inst Mol & Cell Biol IMCB, Lab NF B Signalling, 61 Biopolis Dr, Singapore 138673, Singapore

[14] Natl Univ Singapore, NUS Ctr Canc Res N2CR, Yong Loo Lin Sch Med, Singapore 117599, Singapore

[15] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA

[16] Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA

[17] China Med Univ, Dept Breast Surg, Hosp 1, 155 North Nanjing St, Shenyang 110001, Liaoning, Peoples R China

来源：

AGEING RESEARCH REVIEWS | 2024年 / 100卷

基金：

新加坡国家研究基金会; 加拿大健康研究院;

关键词：

Aging; autophagy; cancer therapy; cell death; longevity; CHAPERONE-MEDIATED AUTOPHAGY; LIFE-SPAN EXTENSION; TERM CALORIC RESTRICTION; PROGRAMMED CELL-DEATH; STARVATION-INDUCED AUTOPHAGY; AGE-RELATED-CHANGES; DNA-DAMAGE; MITOCHONDRIAL DYSFUNCTION; OXIDATIVE STRESS; DUAL ROLE;

D O I：

10.1016/j.arr.2024.102428

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Macroautophagy/autophagy is primarily accountable for the degradation of damaged organelles and toxic macromolecules in the cells. Regarding the essential function of autophagy for preserving cellular homeostasis, changes in, or dysfunction of, autophagy flux can lead to disease development. In the current paper, the complicated function of autophagy in aging-associated pathologies and cancer is evaluated, highlighting the underlying molecular mechanisms that can affect longevity and disease pathogenesis. As a natural biological process, a reduction in autophagy is observed with aging, resulting in an accumulation of cell damage and the development of different diseases, including neurological disorders, cardiovascular diseases, and cancer. The MTOR, AMPK, and ATG proteins demonstrate changes during aging, and they are promising therapeutic targets. Insulin/IGF1, TOR, PKA, AKT/PKB, caloric restriction and mitochondrial respiration are vital for lifespan

引用

页数：24

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