Gut Microbiota in Primary Osteoporosis: a Systematic Review

被引：1

作者：

Ji, Jiangxun ^{[1
,2
,3
]}

Cai, Feihong ^{[1
,2
,3
]}

Yuan, Chunchun ^{[1
,2
,3
]}

Huang, Chen ^{[1
,2
,3
]}

Zhang, Haitao ^{[1
,2
,3
]}

Xu, Chuanglong ^{[4
,5
]}

Suo, Wendong ^{[1
,2
,3
]}

Zhu, Wenhao ^{[1
]}

Shi, Binhao ^{[1
,2
,3
,7
]}

Tang, Dezhi ^{[1
,2
,3
]}

Wang, Yongjun ^{[1
,2
,3
,6
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200032, Peoples R China

[2] Minist Educ, Key Lab Theory & Therapy Muscles & Bones, Shanghai 200032, Peoples R China

[3] Shanghai Acad Tradit Chinese Med, Spine Inst, Shanghai 200032, Peoples R China

[4] Ningxia Tradit Chinese Med Hosp, Yinchuan 750021, Peoples R China

[5] Chinese Med Res Ctr, Yinchuan, Peoples R China

[6] Shanghai Univ Tradit Chinese Med, Shanghai 201203, Peoples R China

[7] Shanghai Univ Tradit Chinese Med, Shanghai Municipal Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China

来源：

PHENOMICS | 2024年 / 4卷 / 03期

关键词：

Bone Mineral Status; Osteoporosis; Gut Microbiota; Metagenomes;

D O I：

10.1007/s43657-024-00164-y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The link between gut microbiota (GM) and primary osteoporosis has garnered substantial attention. In this study, we conducted a systematic review encompassing 10 studies that employed high-throughput sequencing methodologies. Notably, the taxonomic profiles exhibited pronounced heterogeneity across reviewed studies. A combined analysis of mechanistical studies screened out potential targets for osteoporosis prevention and treatment. We appraised the limitations in previous studies, and proposed suggestions for optimizing sequencing techniques and experimental designs. Larger-size longitudinal cohorts based on multi-omics and extended phenotypes are recommended to comprehensively characterize the involvement of GM in the pathogenesis of osteoporosis.

引用

页码：293 / 297

页数：5

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