HO-1: An emerging target in fibrosis

被引：0

作者：

Lu, Chenxi ^{[1
]}

Liu, Yuan ^{[1
]}

Ren, Feifei ^{[1
]}

Zhang, Haoran ^{[1
]}

Hou, Yafang ^{[1
]}

Zhang, Hong ^{[1
]}

Chen, Zhiyong ^{[1
]}

Du, Xia ^{[1
]}

机构：

[1] Shaanxi Acad Tradit Chinese Med, Inst Tradit Chinese Med, Xian 710003, Peoples R China

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2025年 / 240卷 / 01期

基金：

中国国家自然科学基金;

关键词：

extracellular matrix; fibrosis; HO-1; molecular mechanism; HEME OXYGENASE-1 GENE; HEPATIC STELLATE CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; INDUCED PULMONARY-FIBROSIS; INDUCED LUNG FIBROSIS; NF-KAPPA-B; LIVER FIBROSIS; ENDOTHELIAL-CELLS; CARDIAC FIBROSIS; TRANSCRIPTION FACTORS;

D O I：

10.1002/jcp.31465

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Fibrosis, an aberrant reparative response to tissue injury, involves a disruption in the equilibrium between the synthesis and degradation of the extracellular matrix, leading to its excessive accumulation within normal tissues, and culminating in organ dysfunction. Manifesting in the terminal stages of nearly all chronic ailments, fibrosis carries a high mortality rate and poses a significant threat to human health. Heme oxygenase-1 (HO-1) emerges as an endogenous protective agent, mitigating tissue damage through its antioxidant, anti-inflammatory, and antiapoptotic properties. Numerous studies have corroborated HO-1's potential as a therapeutic target in anti-fibrosis treatment. This review delves into the structural and functional attributes, and the upstream and downstream pathways of HO-1. Additionally, the regulatory networks and mechanisms of HO-1 in cells associated with fibrosis are elucidated. The role of HO-1 in various fibrosis-related diseases is also explored. Collectively, this comprehensive information serves as a foundation for future research and augments the viability of HO-1 as a therapeutic target for fibrosis. Overview of the molecular mechanism of heme oxygenase-1 in fibrosis development. image

引用

页数：20

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