Effects of glucocorticoid replacement therapy in patients with pituitary disease: A new perspective for personalized replacement therapy

被引：0
作者：
Chiloiro, Sabrina [1 ,2 ]
Vicari, Alessandra [1 ,2 ]
Mongelli, Ginevra [1 ,2 ]
Costanza, Flavia [1 ,2 ]
Giampietro, Antonella [1 ,2 ]
Mattogno, Pier Paolo [3 ,4 ]
Lauretti, Liverana [3 ,4 ]
Olivi, Alessandro [3 ,4 ]
De Marinis, Laura [1 ,2 ]
Doglietto, Francesco [3 ,4 ]
Bianchi, Antonio [1 ,2 ]
Pontecorvi, Alfredo [1 ,2 ]
机构：
[1] Univ Cattolica Sacro Cuore, Dipartimento Med & Chirurg Traslaz, Rome, Italy
[2] Fdn Policlin Univ A Gemelli, Dept Endocrinol & Diabet, Pituitary Unit, IRCCS, Rome, Italy
[3] Fdn Policlin Univ A Gemelli IRCCS, Dept Neurosurg, Rome, Italy
[4] Univ Cattolica Sacro Cuore, Dept Ageing Neurosci Head Neck & Orthoped Sci, Rome, Italy
来源：
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS | 2024年 / 25卷 / 05期
关键词：
Hypopituitarism; Diabetes insipidus; Pituitary adenoma; Pituitary neuroendocrine tumors; Pit-NET; Craniopharyngiomas; Hypophysitis; Histiocytosis; Germinoma; Metastasis; IPILIMUMAB-INDUCED HYPOPHYSITIS; QUALITY-OF-LIFE; PRIMARY AUTOIMMUNE HYPOPHYSITIS; LANGERHANS CELL HISTIOCYTOSIS; DUAL-RELEASE HYDROCORTISONE; BONE-MINERAL DENSITY; ADRENAL INSUFFICIENCY; SINGLE-CENTER; CLINICAL CHARACTERISTICS; ENDOCRINE;
D O I：
10.1007/s11154-024-09898-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Secondary adrenal insufficiency (SAI) is an endocrine disorder due to impaired secretion of ACTH resulting from any disease affecting the pituitary gland. Glucocorticoid replacement therapy is mandatory to ensure patient survival, haemodynamic stability, and quality of life. In fact, a correct dose adjustement is mandatory due to the fact that inappropriately low doses expose patients to hypoadrenal crisis, while inappropriately high doses contribute to glucose metabolic and cardiovascular deterioration. This review analyses the current evidence from available publications on the epidemiology and aetiology of SAI and examines the association between glucocorticoid replacement therapy and glucometabolic and cardiovascular effects.
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收藏
页码：855 / 873
页数：19
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