Pembrolizumab in HER2-Positive Gastric Cancer

被引：15

作者：

Janjigian, Yelena Y. ^{[1
]}

Kawazoe, Akihito ^{[2
]}

Bai, Yuxian ^{[3
]}

Xu, Jianming ^{[4
]}

Lonardi, Sara ^{[5
]}

Metges, Jean Phillipe ^{[6
]}

Yanez, Patricio ^{[7
]}

Wyrwicz, Lucjan S. ^{[8
]}

Shen, Lin ^{[9
]}

Ostapenko, Yuriy ^{[10
]}

Bilici, Mehmet ^{[11
]}

Chung, Hyun Cheol ^{[12
]}

Shitara, Kohei

Qin, Shukui ^{[13
]}

Van Cutsem, Eric ^{[14
]}

Tabernero, Josep ^{[15
]}

Luo, Suxia ^{[16
]}

Mahave, Mauricio ^{[17
]}

Tang, Yong ^{[18
]}

Lowery, Maeve ^{[19
]}

Monteiro, Maria M. F. ^{[20
]}

Xu, Linzhi ^{[21
]}

Shih, Chie-Schin ^{[21
]}

Sharan, Kanu P. ^{[21
]}

Bhagia, Pooja ^{[21
]}

Rha, Sun Young ^{[12
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, New York, NY 10029 USA

[2] Natl Canc Hosp East, Kashiwa, Japan

[3] Harbin Med Univ Canc Hosp, Harbin, Peoples R China

[4] Fifth Med Ctr Peoples Liberat Army, Beijing, Peoples R China

[5] Ist Oncol Veneto, Padua, Italy

[6] Univ Hosp Brest, Brest, France

[7] James Lind Canc Res Ctr, Temuco, Chile

[8] Maria Sklodowska Curie Natl Canc Res Inst, Warsaw, Poland

[9] Key Lab Carcinogenesis & Translat Res, Beijing, Peoples R China

[10] Natl Canc Inst, Kiev, Ukraine

[11] Ataturk Univ, Erzurum, Turkiye

[12] Yonsei Canc Ctr, Seoul, South Korea

[13] Canc Ctr Peoples Liberat Army, Nanjing, Peoples R China

[14] Univ Hosp Gasthuisberg, Leuven, Belgium

[15] Vall dHebron Univ Hosp, Inst Oncol, Barcelona, Spain

[16] Henan Canc Hosp, Zhengzhou, Peoples R China

[17] Fdn Arturo Lopez Perez, Santiago, Chile

[18] Xinjiang Med Univ, Canc Hosp, Urumqi, Peoples R China

[19] Trinity St Jamess Canc Inst, Dublin, Ireland

[20] Inst Canc Ceara, Fortaleza, CE, Brazil

[21] Merck, Rahway, NJ USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2024年

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1056/NEJMc2408121

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pembrolizumab in HER2-Positive Gastric Cancer The addition of pembrolizumab to trastuzumab and chemotherapy in patients with gastric cancer improved both progression-free and overall survival as compared with trastuzumab and chemotherapy alone.

引用

页数：3

共 50 条

[41] NICE guidance on trastuzumab for the treatment of HER2-positive metastatic gastric cancer [J].

Holden, Joanne ;

Garrett, Zoe ;

Stevens, Andrew .

LANCET ONCOLOGY, 2011, 12 (01) :16-17

[42] Phase II trial of dacomitinib in patients with HER2-positive gastric cancer [J].

Oh, Do-Youn ;

Lee, Kewn-Wook ;

Cho, Jae Yong ;

Kang, Won Ki ;

Im, Seock-Ah ;

Kim, Jin Won ;

Bang, Yung-Jue .

GASTRIC CANCER, 2016, 19 (04) :1095-1103

[43] Second line of treatment for HER2-positive gastric cancer: an evolving issue [J].

Roviello, Giandomenico ;

Catalano, Martina ;

D'Angelo, Alberto ;

Palmieri, Valeria Emma .

REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY, 2021, 26 (02) :316-317

[44] Trastuzumab: A Review of Its Use in HER2-Positive Advanced Gastric Cancer [J].

Sanford, Mark .

DRUGS, 2013, 73 (14) :1605-1615

[45] Advanced HER2-positive gastric cancer: Current and future targeted therapies [J].

Pazo Cid, Roberto A. ;

Anton, Antonio .

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2013, 85 (03) :350-362

[46] HER2-Positive Gastric Cancer: The Role of Immunotherapy and Novel Therapeutic Strategies [J].

Pous, Anna ;

Notario, Lucia ;

Hierro, Cinta ;

Layos, Laura ;

Buges, Cristina .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (14)

[47] LapatinibDevelopment of resistance to metastatic HER2-positive gastric cancer: case report [J].

Reactions Weekly, 2018, 1697 (1) :221-221

[48] Trastuzumab: A Review of Its Use in HER2-Positive Advanced Gastric Cancer [J].

Mark Sanford .

Drugs, 2013, 73 :1605-1615

[49] Antitumor activity of multikinase inhibitors in HER2-positive gastric cancer cells [J].

Yoshioka, Takahiro ;

Shien, Kazuhiko ;

Namba, Kei ;

Torigoe, Hidejiro ;

Sato, Hiroki ;

Yamamoto, Hiromasa ;

Soh, Junichi ;

Asano, Hiroaki ;

Tsukuda, Kazunori ;

Fujiwara, Toshiyoshi ;

Toyooka, Shinichi .

CANCER RESEARCH, 2017, 77

[50] Trastuzumab-based treatment of HER2-positive metastatic gastric cancer [J].

Dogan, I. ;

Karabulut, S. ;

Tastekin, D. ;

Paksoy, N. ;

Sakar, B. ;

Vatansever, S. .

ANNALS OF ONCOLOGY, 2020, 31 :S205-S205

← 1 2 3 4 5 →