Regulatory T cells: masterminds of immune equilibrium and future therapeutic innovations

被引：1

作者：

Ge, Junwei ^{[1
,2
,3
]}

Yin, Xuan ^{[1
,2
,3
]}

Chen, Lujun ^{[1
,2
,3
]}

机构：

[1] Soochow Univ, Dept Tumor Biol Treatment, Affiliated Hosp 3, Changzhou, Jiangsu, Peoples R China

[2] Soochow Univ, Jiangsu Engn Res Ctr Tumor Immunotherapy, Affiliated Hosp 3, Changzhou, Jiangsu, Peoples R China

[3] Soochow Univ, Affiliated Hosp 3, Inst Cell Therapy, Changzhou, Jiangsu, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷

基金：

中国国家自然科学基金;

关键词：

Treg; autoimmune diseases; cancer; immunotherapy; checkpoint inhibitors; 1ST-LINE PEMBROLIZUMAB; TREG DIFFERENTIATION; FOXP3; EXPRESSION; DENDRITIC CELLS; LUNG-CANCER; IMMUNOTHERAPY; NIVOLUMAB; EXPANSION; COMBINATION; SUPPRESSION;

D O I：

10.3389/fimmu.2024.1457189

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory T cells (Tregs), a subset of CD4+T cells marked by the expression of the transcription factor forkhead box protein 3 (Foxp3), are pivotal in maintaining immune equilibrium and preventing autoimmunity. In our review, we addressed the functional distinctions between Foxp3+Tregs and other T cells, highlighting their roles in autoimmune diseases and cancer. We uncovered the dual nature of Tregs: they prevented autoimmune diseases by maintaining self-tolerance while contributing to tumor evasion by suppressing anti-tumor immunity. This study underscored the potential for targeted therapeutic strategies, such as enhancing Treg activity to restore balance in autoimmune diseases or depleting Foxp3+Tregs to augment anti-tumor immune responses in cancer. These insights laid the groundwork for future research and clinical applications, emphasizing the critical role of Foxp3+Tregs in immune regulation and the advancement of next-generation immunotherapies.

引用

页数：17

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