Different Types of Cell Death in Diabetic Neuropathy: A Focus on Mechanisms and Therapeutic Strategies

被引：4

作者：

Ye, Shang ^{[1
]}

Cheng, Zilin ^{[1
]}

Zhuo, Dongye ^{[1
]}

Liu, Shuangmei ^{[2
]}

机构：

[1] Nanchang Univ, Jiangxi Med Coll, Sch Queen Mary, Dept Clin Med, Nanchang 330031, Peoples R China

[2] Nanchang Univ, Jiangxi Med Coll, Sch Basic Med, Dept Physiol, Nanchang 330031, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 15期

基金：

中国国家自然科学基金;

关键词：

diabetic neuropathy; cell death; apoptosis; autophagy; pyroptosis; ferroptosis; ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; OXIDATIVE-STRESS; PERIPHERAL NEUROPATHY; INDUCED APOPTOSIS; DORSAL-HORN; RAT MODEL; PAIN; AUTOPHAGY; FERROPTOSIS;

D O I：

10.3390/ijms25158126

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diabetic neuropathy (DN) is a common complication of diabetes, affecting over 50% of patients, leading to significant pain and a burden. Currently, there are no effective treatments available. Cell death is considered a key factor in promoting the progression of DN. This article reviews how cell death is initiated in DN, emphasizing the critical roles of oxidative stress, mitochondrial dysfunction, inflammation, endoplasmic reticulum stress, and autophagy. Additionally, we thoroughly summarize the mechanisms of cell death that may be involved in the pathogenesis of DN, including apoptosis, autophagy, pyroptosis, and ferroptosis, among others, as well as potential therapeutic targets offered by these death mechanisms. This provides potential pathways for the prevention and treatment of diabetic neuropathy in the future.

引用

页数：20

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