Acquired Aplastic Anemia Therapies: Immunosuppressive Therapy Versus Alternative Donor Hematopoietic Cell Transplantation

被引：0
作者：
Wirk, Baldeep [1 ]
机构：
[1] Virginia Commonwealth Univ, Massey Comprehens Canc Ctr, Cellular Immunotherapies & Transplant Program, Richmond, VA 23219 USA
来源：
JOURNAL OF HEMATOLOGY | 2024年 / 13卷 / 03期
关键词：
Aplastic anemia; Immunosuppressive therapy; Stem cell transplantation; PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA; POSTTRANSPLANT CYCLOPHOSPHAMIDE; ELTROMBOPAG; OUTCOMES; MUTATIONS; DIAGNOSIS; LEUKEMIA; BLOOD;
D O I：
10.14740/jh1264
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Immunosuppressive therapy for acquired severe aplastic anemia improves pancytopenia but has a significant risk of relapse (40%) and clonal evolution to myeloid neoplasms (15%), especially in patients older than 40. Yet, current guidelines for newly diagnosed severe aplastic anemia patients over the age of 40 recommend immunosuppressive therapy instead of curative allogeneic stem cell transplantation. Upfront allogeneic stem cell transplants are restricted to the rare patient who is not only young but also has a matched sibling donor. This article will discuss practice-changing data on the recent advances in upfront alternative donor hematopoietic cell transplants that could rewrite current treatment algorithms.
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页码：61 / 70
页数：10
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