"Cardiac glycosides"-quo vaditis?-past, present, and future?

被引：1
作者：
Fender, Julia [1 ]
Kloecker, Johanna [1 ]
Boivin-Jahns, Valerie [1 ]
Ravens, Ursula [2 ]
Jahns, Roland [3 ]
Lorenz, Kristina [1 ,4 ]
机构：
[1] Univ Wurzburg, Inst Pharmacol & Toxicol, Versbacher Str 9, D-97078 Wurzburg, Germany
[2] Univ Freiburg, Inst Expt Cardiovasc Med, Fac Med, Elsasser Str 2Q, D-79110 Freiburg, Germany
[3] Univ Hosp Wurzburg, Interdisciplinary Bank Biol Mat & Data Wurzburg ib, Straubmuhlweg 2a, D-97078 Wurzburg, Germany
[4] Leibniz Inst Analyt Wissensch ISAS eV, Bunsen Kirchhoff Str 11, D-44139 Dortmund, Germany
来源：
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2024年 / 397卷 / 12期
关键词：
Digitalis glycosides; Cardiac glycosides; NKA inhibitors; Digoxin; Digitoxin; Na+/K+-ATPase; Heart failure; Atrial fibrillation; Toxicity; Metabolism; Cancer; NA+-K+-ATPASE; HEART-FAILURE; CARDIOTONIC STEROIDS; DIGOXIN; DIGITALIS; DIGITOXIN; PHARMACOKINETICS; NA; K-ATPASE; BINDING; EXPRESSION;
D O I：
10.1007/s00210-024-03285-3
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Up to date, digitalis glycosides, also known as "cardiac glycosides", are inhibitors of the Na+/K+-ATPase. They have a long-standing history as drugs used in patients suffering from heart failure and atrial fibrillation despite their well-known narrow therapeutic range and the intensive discussions on their raison d'& ecirc;tre for these indications. This article will review the history and key findings in basic and clinical research as well as potentially overseen pros and cons of these drugs.
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收藏
页码：9521 / 9531
页数：11
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