State-of-the-Art and New Treatment Approaches for Spinal Cord Tumors

被引:0
作者
Kumawat, Chetan [1 ,2 ]
Takahashi, Toshiyuki [3 ]
Date, Isao [4 ]
Tomita, Yousuke [4 ]
Tanaka, Masato [1 ]
Arataki, Shinya [1 ]
Komatsubara, Tadashi [1 ]
Flores, Angel O. P. [1 ]
Yu, Dongwoo [1 ]
Jain, Mukul [1 ]
机构
[1] Okayama Rosai Hosp, Dept Orthoped Surg, 1-10-25 Chikkomidorimachi, Okayama 7028055, Japan
[2] Sir Ganga Ram Hosp, Dept Orthoped Surg, New Delhi 110060, India
[3] Fujieda Heisei Mem Hosp, Spinal Disorder Ctr, 123-1 Mizuue Fujieda, Shizuoka 4268662, Japan
[4] Okayama Rosai Hosp, Dept Neurosurg, 1-10-25 Chikkomidorimachi, Okayama 7028055, Japan
关键词
spinal cord tumor; astrocytoma; diagnosis; current treatment; surgery; CENTRAL-NERVOUS-SYSTEM; PHASE-II; INTRAOPERATIVE ULTRASOUND; SURGICAL-MANAGEMENT; MAGNETIC-RESONANCE; RESECTION; GLIOMA; BRAIN; TEMOZOLOMIDE; RECURRENT;
D O I
10.3390/cancers16132360
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Simple Summary Spinal cord tumors encompass a diverse range of rare neoplasms originating from tissues in and around the spinal canal. Traditional treatment modalities like surgery, radiation therapy, and chemotherapy have been the mainstay for managing these tumors. Nowadays, advancements in gene therapy, immunotherapy, and targeted therapy are offering groundbreaking possibilities. This article outlines the available and developing options for diagnosis and such treatments.Abstract Spinal cord tumors, though rare, present formidable challenges in clinical management due to their intricate nature. Traditional treatment modalities like surgery, radiation therapy, and chemotherapy have been the mainstay for managing these tumors. However, despite significant advancements, challenges persist, including the limitations of surgical resection and the potential side effects associated with radiation therapy. In response to these limitations, a wave of innovative approaches is reshaping the treatment landscape for spinal cord tumors. Advancements in gene therapy, immunotherapy, and targeted therapy are offering groundbreaking possibilities. Gene therapy holds the potential to modify the genes responsible for tumor growth, while immunotherapy harnesses the body's own immune system to fight cancer cells. Targeted therapy aims to strike a specific vulnerability within the tumor cells, offering a more precise and potentially less toxic approach. Additionally, novel surgical adjuncts are being explored to improve visualization and minimize damage to surrounding healthy tissue during tumor removal. These developments pave the way for a future of personalized medicine for spinal cord tumors. By delving deeper into the molecular makeup of individual tumors, doctors can tailor treatment strategies to target specific mutations and vulnerabilities. This personalized approach offers the potential for more effective interventions with fewer side effects, ultimately leading to improved patient outcomes and a better quality of life. This evolving landscape of spinal cord tumor management signifies the crucial integration of established and innovative strategies to create a brighter future for patients battling this complex condition.
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页数:22
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