Histopathological changes in salivary glands after radioactive iodine treatment for thyroid diseases

被引:0
作者
Li, Xiao [1 ]
Su, Jia-Zeng [1 ]
Gao, Yan [2 ]
Liu, Deng-Gao [3 ]
Yu, Guang-Yan [1 ]
机构
[1] Peking Univ, Sch & Hosp Stomatol, Natl Engn Lab Digital & Mat Technol Stomatol, Dept Oral & Maxillofacial Surg,Beijing Key Lab Dig, Beijing, Peoples R China
[2] Peking Univ, Beijing Key Lab Digital Stomatol, Natl Engn Lab Digital & Mat Technol Stomatol, Dept Oral Pathol,Sch & Hosp Stomatol, Beijing, Peoples R China
[3] Peking Univ, Natl Engn Lab Digital & Mat Technol Stomatol, Beijing Key Lab Digital Stomatol, Dept Oral Radiol,Sch & Hosp Stomatol, Beijing, Peoples R China
来源
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY | 2024年 / 138卷 / 03期
关键词
2ND PRIMARY MALIGNANCY; I-131; TREATMENT; PRIMARY-CANCER; ADULT PATIENTS; DYSFUNCTION; RISK; ASSOCIATION; RADIATION;
D O I
10.1016/j.oooo.2024.05.003
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Objectives. We aimed to evaluate the histopathological alterations in human salivary glands after radioactive iodine (RAI) treatment for thyroid diseases. Study Design. We retrospectively selected patients with a history of RAI treatment for thyroid diseases from a database of patients who underwent surgery for oral and maxillofacial diseases and had specimens of salivary glands at Peking University School of Stomatology between December 2012 and July 2023. The patients' clinical records and histopathological slides of the salivary glands were carefully reviewed. Results. Sixteen patients were included. Three symptomatic patients showed duct cell cytoplasmic vacuolization and increased numbers of disordered duct cell layers (3/3), severe duct stenosis and dilation (2/3), and exfoliated epithelial cells in the duct lumen (1/3). The glandular parenchyma showed severe acinar atrophy (2/2), fat content enhancement (2/2), and severe periductal fibrosis (3/3). Thirteen asymptomatic patients showed duct cell cytoplasmic vacuolization (5/13), acinar atrophy and increased fat content in the parenchyma (5/13), and periductal fibrosis (5/13). Conclusion. Main histopathologic changes in the salivary glands after RAI treatment for thyroid diseases are cytoplasmic vacuolization of duct cells, acinar atrophy, fat content enhancement, and periductal fibrosis. These changes were evident in symptomatic cases, and were also seen in some asymptomatic patients. (Oral Surg Oral Med Oral Pathol Oral Radiol 2024;138:384-390)
引用
收藏
页码:384 / 390
页数:7
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