Disruptive and complementary effects of depression symptoms on spontaneous brain activity in the subcortical vascular mild cognitive impairment

被引:0
|
作者
Hu, Liyu [1 ,2 ]
Chen, Jianxiang [3 ]
Li, Xinbei [3 ]
Zhang, Haoran [2 ]
Zhang, Jinhuan [1 ]
Lu, Yingqi [2 ]
Lian, Jie [4 ]
Yu, Haibo [1 ]
Yang, Nan [5 ]
Wang, Jianjun [4 ]
Lyu, Hanqing [3 ]
Xu, Jinping [2 ]
机构
[1] Guangzhou Univ Chinese Med, Shenzhen Tradit Chinese Med Hosp, Clin Med Coll 4, Dept Acupuncture & Moxibust, Shenzhen, Peoples R China
[2] Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Hlth Engn, Shenzhen, Peoples R China
[3] Guangzhou Univ Chinese Med, Shenzhen Tradit Chinese Med Hosp, Clin Med Coll 4, Dept Radiol, Shenzhen, Peoples R China
[4] Guangzhou Univ Chinese Med, Shenzhen Tradit Chinese Med Hosp, Clin Med Coll 4, Dept Neurol & Psychiat, Shenzhen, Peoples R China
[5] Hosp Tradit Chinese Med Zhongshan, Zhongshan, Peoples R China
来源
FRONTIERS IN AGING NEUROSCIENCE | 2024年 / 16卷
关键词
subcortical vascular mild cognitive impairment; depression symptoms; fractions of amplitude of low-frequency fluctuations; resting-state functional connectivity; support vector machine; RESTING-STATE FMRI; LOW-FREQUENCY OSCILLATIONS; GRAY-MATTER VOLUMES; FUNCTIONAL CONNECTIVITY; ALZHEIMERS-DISEASE; NEUROPSYCHIATRIC SYMPTOMS; REGIONAL HOMOGENEITY; POSTERIOR CINGULATE; DEMENTIA; AMPLITUDE;
D O I
10.3389/fnagi.2024.1338179
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background Although depression symptoms are commonly reported in patients with subcortical vascular mild cognitive impairment (svMCI), their impact on brain functions remains largely unknown, with diagnoses mainly dependent on behavioral assessments.Methods In this study, we analyzed resting-state fMRI data from a cohort of 34 svMCI patients, comprising 18 patients with depression symptoms (svMCI+D) and 16 patients without (svMCI-D), along with 34 normal controls (NC). The study used the fraction of the amplitude of low-frequency fluctuations (fALFF), resting-state functional connectivity, correlation analyses, and support vector machine (SVM) techniques.Results The fALFF of the right cerebellum (CERE.R) differed among the svMCI+D, svMCI-D, and NC groups. Specifically, the regional mean fALFF of CERE. R was lower in svMCI-D patients compared to NC but higher in svMCI+D patients compared to svMCI-D patients. Moreover, the adjusted fALFF of CERE. R showed a significant correlation with Montreal Cognitive Assessment (MOCA) scores in svMCI-D patients. The fALFF of the right orbital part of the superior frontal gyrus was significantly correlated with Hamilton Depression Scale scores in svMCI+D patients, whereas the fALFF of the right postcingulate cortex (PCC.R) showed a significant correlation with MOCA scores in svMCI-D patients. Furthermore, RSFC between PCC. R and right precuneus, as well as between CERE. R and the right lingual gyrus (LING.R), was significantly reduced in svMCI-D patients compared to NC. In regional analyses, the adjusted RSFC between PCC. R and PreCUN. R, as well as between CERE. R and LING. R, was decreased in svMCI-D patients compared to NC but increased in svMCI+D patients compared to svMCI-D. Further SVM analyses achieved good performances, with an area under the curve (AUC) of 0.82 for classifying svMCI+D, svMCI-D, and NC; 0.96 for classifying svMCI+D and svMCI-D; 0.82 for classifying svMCI+D and NC; and 0.92 for classifying svMCI-D and NC.Conclusion The study revealed disruptive effects of cognitive impairment, along with both disruptive and complementary effects of depression symptoms on spontaneous brain activity in svMCI. Moreover, these findings suggest that the identified features might serve as potential biomarkers for distinguishing between svMCI+D, svMCI-D, and NC, thereby guiding clinical treatments such as transcranial magnetic stimulation for svMCI.
引用
收藏
页数:10
相关论文
共 50 条
  • [1] Structural and Functional Disruptions in Subcortical Vascular Mild Cognitive Impairment With and Without Depressive Symptoms
    Lyu, Hanqing
    Wang, Jianjun
    Xu, Jinping
    Zheng, Haotao
    Yang, Xiaoyan
    Lin, Songjun
    Chen, Jianxiang
    Zhou, Liuchang
    Hu, Yuanming
    Guo, Zhouke
    FRONTIERS IN AGING NEUROSCIENCE, 2019, 11
  • [2] Written Spelling in Patients with Subcortical Vascular Dementia and Subcortical Vascular Mild Cognitive Impairment
    Shin, Joon Soo
    Jang, Hyemin
    Kim, Hee Jin
    Na, Duk L.
    Yoon, Ji Hye
    COMMUNICATION SCIENCES AND DISORDERS-CSD, 2022, 27 (02): : 297 - 312
  • [3] Neurobehavioral Dysfunction in Patients with Subcortical Vascular Mild Cognitive Impairment and Subcortical Vascular Dementia
    Chin, Juhee
    Seo, Sang Won
    Kim, Sook Hui
    Park, Aram
    Ahn, Hyun-Jung
    Lee, Byung Hwa
    Kang, Sue J.
    Na, Duk L.
    CLINICAL NEUROPSYCHOLOGIST, 2012, 26 (02) : 224 - 238
  • [4] Alterations of White Matter Microstructure in Subcortical Vascular Mild Cognitive Impairment with and without Depressive Symptoms
    Xu, Ziyun
    Wang, Jianjun
    Lyu, Hanqing
    Wang, Runshi
    Hu, Yuanming
    Guo, Zhouke
    Xu, Jinping
    Hu, Qingmao
    JOURNAL OF ALZHEIMERS DISEASE, 2020, 73 (04) : 1565 - 1573
  • [5] Diffusion Tensor Imaging in Subcortical Vascular Mild Cognitive Impairment and Subcortical Ischemic Vascular Dementia
    Kim, So-Hyun
    Kim, Sung-Rae
    Choi, Seong Hye
    Rha, Joung-Ho
    Ha, Choong-Kun
    NEUROLOGY, 2009, 72 (11) : A170 - A171
  • [6] Research for cognitive feature of subcortical ischemic vascular dementia and vascular mild cognitive impairment
    Guo, QH
    Hong, Z
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2005, 229 : 322 - 323
  • [7] Subcortical Vascular Dementia Biomarker Pattern in Mild Cognitive Impairment
    Bjerke, Maria
    Andreasson, Ulf
    Rolstad, Sindre
    Nordlund, Arto
    Lind, Karin
    Zetterberg, Henrik
    Edman, Ake
    Blennow, Kaj
    Wallin, Anders
    DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2009, 28 (04) : 348 - 356
  • [8] Altered Whole-Brain Structural Covariance of the Hippocampal Subfields in Subcortical Vascular Mild Cognitive Impairment and Amnestic Mild Cognitive Impairment Patients
    Wang, Xuetong
    Yu, Yang
    Zhao, Weina
    Li, Qiongling
    Li, Xinwei
    Li, Shuyu
    Yin, Changhao
    Han, Ying
    FRONTIERS IN NEUROLOGY, 2018, 9
  • [9] Differential Regional Brain Spontaneous Activity in Subgroups of Mild Cognitive Impairment
    Zhou, Qi-Hui
    Wang, Kun
    Zhang, Xiao-Ming
    Wang, Li
    Liu, Jiang-Hong
    FRONTIERS IN HUMAN NEUROSCIENCE, 2020, 14
  • [10] Different patterns of functional and structural alterations of hippocampal sub-regions in subcortical vascular mild cognitive impairment with and without depression symptoms
    Jinping Xu
    Jianjun Wang
    Hanqing Lyu
    Xuejia Pu
    Ziyun Xu
    Yuanming Hu
    Zhouke Guo
    Haibo Yu
    Qingmao Hu
    Brain Imaging and Behavior, 2021, 15 : 1211 - 1221