Eco-friendly Approaches to Chromene Derivatives: A Comprehensive Review of Green Synthesis Strategies

被引：4

作者：

Patel, Vidhi ^{[1
]}

Bambharoliya, Tushar ^{[2
]}

Shah, Drashti ^{[1
]}

Patel, Dharti ^{[1
]}

Patel, Maitri ^{[1
]}

Shah, Umang ^{[1
]}

Patel, Mehul ^{[1
]}

Patel, Swayamprakash ^{[1
]}

Solanki, Nilay ^{[1
]}

Mahavar, Anjali ^{[3
]}

Nagani, Afzal ^{[4
]}

Patel, Harnisha ^{[4
]}

Rathod, Mrudangsinh ^{[4
]}

Bhimani, Bhargav ^{[5
]}

Bhavsar, Vasisth ^{[6
]}

Padhiyar, Shantilal ^{[6
]}

Koradia, Shailesh ^{[7
]}

Chandarana, Chandni ^{[8
]}

Patel, Bhavesh ^{[9
]}

Dabhi, Ranjitsinh C. ^{[10
]}

Patel, Ashish ^{[1
]}

机构：

[1] Charotar Univ Sci & Technol, Ramanbhai Patel Coll Pharm, CHARUSAT Campus, Anand 388421, Gujarat, India

[2] North Carolina State Univ, Dept Fiber & Polymer Sci, Raleigh, NC USA

[3] Charotar Univ Sci & Technol, Chandaben Mohanbhai Patel Inst Comp Applicat, CHARUSAT Campus, Changa 388421, Gujarat, India

[4] Parul Univ, Dept Pharmaceut Chem, Vadodara 391760, Gujarat, India

[5] Piramal Pharm Ltd, Pharmaceut Special Econ Zone, Ahmadabad 388213, India

[6] Dharmsinh Desai Univ, Fac Pharm, Nadiad, Gujarat, India

[7] Drs Kiran & Pallavi Patel Global Univ, Krishna Sch Pharm & Res, Dept Pharmaceut Chem & Qual Assurance, Vadodara 391423, Gujarat, India

[8] SSR Coll Pharm, Dept Qual Assurance, Silvassa 396230, India

[9] Navinta LLC, Dept Pharmaceut Technol, Ewing Township, NJ USA

[10] Gujarat Univ, Sch Sci, Dept Chem, Ahmadabad 380009, Gujarat, India

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2025年 / 25卷 / 05期

关键词：

Chromene; Microwave synthesis; Green solvent; Ultrasound-assisted; Green chemistry; ONE-POT SYNTHESIS; MICROWAVE-ASSISTED SYNTHESIS; THROUGHPUT SCREENING ASSAY; METAL-ORGANIC FRAMEWORK; N-ALLYL QUINOLONE; 2-AMINO-4H-CHROMENE DERIVATIVES; 4H-CHROMENE DERIVATIVES; ANTIMICROBIAL ACTIVITY; SUBSTITUTED; 4H-CHROMENES; 3-COMPONENT SYNTHESIS;

D O I：

10.2174/0115680266305231240712104736

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthetic routes of chromene are an area of thrust research due to its wide application as pigments, agrochemicals, cosmetics, and an important nucleus scaffold for various pharmacologically active drugs. The chromene nucleus is an important moiety for the discovery of new drug candidates owing to its broad range of pharmacological actions like antitumor, anti-inflammatory, antiviral, and many others. However, traditional synthesis techniques frequently use unsafe reagents and produce hazardous waste, presenting environmental issues. The eco-friendly production of chromene derivatives utilizes sustainable raw materials, non-toxic catalysts, and gentle reaction conditions to reduce ecological consequences. Innovative methods like microwave irradiation, ultrasound synthesis, the use of environmentally friendly solvents, a catalyst-based approach with minimal environmental impact, and mechanochemistry-mediated synthesis are implemented. These approaches provide benefits in scalability, cost-effectiveness, and ease of purification. This review compiles and presents various recently reported green synthetic strategies of chromene and its derivatives and gives the reader a clear idea of the detailed and critical aspects of various synthetic protocols described.

引用

页码：437 / 460

页数：24

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