Synthesis of Substituted 1-Benzyl-2H-1,2,3-Triazoles by a Click Reaction Using Calcium Carbide as an Acetylene Source

被引：0

作者：

Fu, Rugang ^{[1
]}

Lei, Yuming ^{[2
]}

Wang, Yuyu ^{[1
]}

Huang, Baoqian ^{[1
]}

Qiu, Dong ^{[1
]}

Wang, Junke ^{[1
]}

机构：

[1] Hexi Univ, Coll Chem & Chem Engn, Key Lab Hexi Corridor Resources Utilizat Gansu, Zhangye 734000, Gansu, Peoples R China

[2] Hexi Univ, Coll Agr & Ecol Engn, Key Lab Hexi Corridor Resources Utilizat Gansu, Zhangye 734000, Gansu, Peoples R China

来源：

SYNLETT | 2024年

基金：

中国国家自然科学基金;

关键词：

sodium azide; calcium carbide; click chemistry; benzyl halides; triazoles; ONE-POT SYNTHESIS; 3+2 CYCLOADDITION REACTIONS; 1,3-DIPOLAR CYCLOADDITION; EFFICIENT SYNTHESIS; SECONDARY-AMINES; 1,2,3-TRIAZOLES; CHEMISTRY; FACILE;

D O I：

10.1055/a-2414-2708

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An effective strategy for constructing substituted 1-benzyl-1H-1,2,3-triazoles was developed through click reactions of benzylic halides with sodium azide and calcium carbide as sources of nitrogen and acetylene, respectively. The advantages of this method are an easily handled inexpensive source of acetylene, a wide range of substrates, satisfactory yields, and simple workup procedures, which could promote the use of calcium carbide as a sustainable acetylene source in modern industrial chemistry.

引用

页数：5

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