The article reports the results of three studies that compare the effects of experiential avoidance and rumination on depression among college students. Study 1 (N = 748) evaluated the cross-sectional association among rumination, experiential avoidance, and depression. Study 2 (N = 887) was a replication of Study I. In Study 3, a subsample of 72 females was drawn from the larger sample of Study 1. In this prospective, longitudinal study, it was estimated whether rumination and experiential avoidance at Time]. (the beginning of the semester) predicted depression symptoms 8 to 1.2 weeks later. When these constructs were measured cross-sectionally in Studies I. and 2, an interaction effect was found between avoidance and rumination; avoidance was only associated with depression symptoms when rumination was high. No interaction was found in the longitudinal study Neither rumination nor experiential avoidance predicted depression symptoms at Time 2 when depression symptoms at Time I were entered as a covariate. These results are discussed with reference to future directions in comparing different dimensions of coping as they relate to depression.