Recent advances in anti-inflammation via AMPK activation

被引：14

作者：

Xu, Yihua ^{[1
]}

Bai, Lan ^{[2
,3
,4
]}

Yang, Xinwei ^{[5
]}

Huang, Jianli ^{[6
]}

Wang, Jie ^{[6
]}

Wu, Xianbo ^{[5
]}

Shi, Jianyou ^{[2
,3
,4
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Sch Basic Med Sci, Chengdu, Sichuan, Peoples R China

[2] Univ Elect Sci & Technol China, Sichuan Acad Med Sci, Dept Pharm, Personalized Drug Therapy Key Lab Sichuan Prov, Chengdu, Sichuan, Peoples R China

[3] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Chengdu, Sichuan, Peoples R China

[4] Chengdu Univ Tradit Chinese Med, Dept Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu, Sichuan, Peoples R China

[5] Chengdu Sport Univ, Sch Sports Med & Hlth, Chengdu, Sichuan, Peoples R China

[6] Guizhou Univ Tradit Chinese Med, Guiyang, Guizhou, Peoples R China

来源：

HELIYON | 2024年 / 10卷 / 13期

基金：

中国国家自然科学基金;

关键词：

AMPK; Inflammation; SIRT; Inflammasome; NF-KB; Treatment; ENDOPLASMIC-RETICULUM STRESS; ADIPOSE-TISSUE THERMOGENESIS; FATTY LIVER-DISEASE; PROTEIN-KINASE; OXIDATIVE STRESS; ANTIINFLAMMATORY ACTIVITY; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; NLRP3; INFLAMMASOME; HYPOTHALAMIC AMPK;

D O I：

10.1016/j.heliyon.2024.e33670

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Inflammation is a complex physiological phenomenon, which is the body's defensive response, but abnormal inflammation can have adverse effects, and many diseases are related to the inflammatory response. AMPK, as a key sensor of cellular energy status, plays a crucial role in regulating cellular energy homeostasis and glycolipid metabolism. In recent years, the antiinflammation effect of AMPK and related signalling cascade has begun to enter everyone's field of vision - not least the impact on metabolic diseases. A great number of studies have shown that anti-inflammatory drugs work through AMPK and related pathways. Herein, this article summarises recent advances in compounds that show anti-inflammatory effects by activating AMPK and attempts to comment on them.

引用

页数：22

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