Features of Pd-catalyzed reactions of allylic acetates elimination in racemic cloprostenol methyl ester triacetate and 15-acetate of methyl ester 11-deoxyprostaglandin E1

被引：0

作者：

Zagitov, Vadim V. ^{[1
]}

Khursan, Sergey L. ^{[1
]}

Vostrikov, Nikolay S. ^{[1
]}

Lobov, Alexander N. ^{[1
]}

Petrova, Svetlana F. ^{[1
]}

Miftakhov, Mansur S. ^{[1
]}

机构：

[1] RAS, Ufa Inst Chem UFRC, 69 Pr Oktyabrya, Ufa 450054, Russia

来源：

TETRAHEDRON | 2024年 / 166卷

关键词：

Prostaglandin; Cloprostenol; Allylic acetate; Elimination; Reductive elimination; Palladium; SILYL ENOL ETHERS; PALLADIUM; FUNCTIONALIZATION; ALKYLATION;

D O I：

10.1016/j.tet.2024.134215

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An exclusively stereoselective reaction of AcOH elimination in the title acetate of cloprostenol was described, which led with high yield under Pd(PPh3)(4)-NaH-THF catalysis to the corresponding 13E,15Z-derivative. In contrast, under the same conditions, the use of methyl ester of 15-acetate 11-deoxyprostaglandin E1 results in regioisomeric reductive elimination products.

引用

页数：6

共 20 条

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