Crosstalk between gut microbiota and cellular senescence: a vicious cycle leading to aging gut

被引：20

作者：

Kawamoto, Shimpei ^{[1
]}

Hara, Eiji ^{[1
,2
,3
]}

机构：

[1] Osaka Univ, Dept Mol Microbiol, Res Inst Microbial Dis RIMD, Suita 5650871, Japan

[2] Osaka Univ, Immunol Frontier Res Ctr, Osaka 5650871, Japan

[3] Osaka Univ, Ctr Infect Dis Educ & Res, Suita 5650871, Japan

来源：

TRENDS IN CELL BIOLOGY | 2024年 / 34卷 / 08期

基金：

日本科学技术振兴机构; 日本学术振兴会;

关键词：

ONCOGENE-INDUCED SENESCENCE; IGA DEFICIENCY; REPLICATIVE SENESCENCE; CELLS; EXPRESSION; AUTOIMMUNITY; SUPPRESSION; DYSBIOSIS; SELECTION;

D O I：

10.1016/j.tcb.2023.12.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Two phenomena, the accumulation of senescent cells and changes in the gut microbiota, are thought to contribute to the decline of biological functions and the development of diseases associated with aging. However, the relationship between these two phenomena and their effects on aging remains to be clarified. Recently, we have reported that gut bacteria induce cellular senescence in ileal germinal center (GC) B cells, resulting in decreased IgA production and diversity. This, in turn, leads to an imbalance in the gut microbiota. Thus, the crosstalk between the gut microbiota and cellular senescence via the host immune system may establish a vicious cycle and contribute to the disruption of gut homeostasis associated with aging.

引用

页码：626 / 635

页数：10

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