The scheduling of adolescence with Netrin-1 and UNC5C

被引：0

作者：

Hoops, Daniel ^{[1
,2
]}

Kyne, Robert ^{[3
]}

Salameh, Samer ^{[2
,4
]}

MacGowan, Del ^{[2
,4
]}

Avramescu, Radu Gabriel ^{[1
,2
]}

Ewing, Elise ^{[2
,4
]}

He, Alina Tao ^{[2
,4
]}

Orsini, Taylor ^{[2
,4
]}

Durand, Anais ^{[2
,4
]}

Popescu, Christina ^{[2
,4
]}

Zhao, Janet Mengyi ^{[2
,4
]}

Shatz, Kelcie ^{[5
]}

Li, LiPing ^{[5
]}

Carroll, Quinn ^{[5
]}

Liu, Guofa ^{[6
]}

Paul, Matthew J. ^{[3
,5
]}

Flores, Cecilia ^{[1
,2
,7
,8
]}

机构：

[1] McGill Univ, Dept Psychiat, Montreal, PQ, Canada

[2] Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada

[3] SUNY Buffalo, Neurosci Program, Buffalo, NY USA

[4] McGill Univ, Integrated Program Neurosci, Montreal, PQ, Canada

[5] SUNY Buffalo, Dept Psychol, Buffalo, NY USA

[6] Univ Toledo, Dept Biol Sci, Toledo, OH USA

[7] McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ, Canada

[8] McGill Univ, Ludmer Ctr Neuroinformat & Mental Hlth, Montreal, PQ, Canada

来源：

ELIFE | 2024年 / 12卷

基金：

加拿大健康研究院; 美国国家科学基金会; 芬兰科学院;

关键词：

axonal pathfinding; behavioural inhibition; neurodevelopment; prefrontal cortex; dopamine system; Mouse; Siberian hamster; MEDIAL PREFRONTAL CORTEX; MALE DJUNGARIAN HAMSTER; RAT CEREBRAL-CORTEX; AGE-OF-ONSET; TYROSINE-HYDROXYLASE; DOPAMINERGIC INNERVATION; REPRODUCTIVE DEVELOPMENT; PHODOPUS-SUNGORUS; BRAIN; PHOTOPERIOD;

D O I：

10.7554/eLife.88261; 10.7554/eLife.88261.4.sa1; 10.7554/eLife.88261.4.sa2; 10.7554/eLife.88261.4.sa3; 10.7554/eLife.88261.4.sa4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dopamine axons are the only axons known to grow during adolescence. Here, using rodent models, we examined how two proteins, Netrin-1 and its receptor, UNC5C, guide dopamine axons toward the prefrontal cortex and shape behaviour. We demonstrate in mice (Mus musculus) that dopamine axons reach the cortex through a transient gradient of Netrin-1-expressing cells - disrupting this gradient reroutes axons away from their target. Using a seasonal model (Siberian hamsters; Phodopus sungorus) we find that mesocortical dopamine development can be regulated by a natural environmental cue (daylength) in a sexually dimorphic manner - delayed in males, but advanced in females. The timings of dopamine axon growth and UNC5C expression are always phase-locked. Adolescence is an ill-defined, transitional period; we pinpoint neurodevelopmental markers underlying this period.

引用

页数：33

共 80 条

[1] Use of the light/dark test for anxiety in adult and adolescent male rats [J].